Eradication of tumors with pre-existing antigenic heterogeneity by vaccine-mediated co-engagement of CAR T and endogenous T-cells
L. Ma, D. M. Morgan, I. Sulkaj, P. Yousefpour, C. A. Whittaker, W. Abraham, N. Li, J. C. Love, D. J. Irvine
This study shows vaccine boosting of CAR T-cells enhances tumor eradication by promoting antigen spreading and endogenous T-cell engagement, even in antigen-negative tumors.
bioRxiv · Oct 5, 2022 · PreprintImmunology