D. M. Morgan

Interferon-γ signaling in eosinophilic esophagitis has implications for epithelial barrier function and programmed cell death.

This study investigates interferon-γ signaling in eosinophilic esophagitis, showing its impact on epithelial barrier function and apoptosis in esophageal epithelial cells.

Differentiation and Expansion of Tumor-Infiltrating T Cell Clonotypes Occurs in the Spleen Following Immune Checkpoint Blockade

This study identifies spleen-resident intermediate-exhausted T cells as key to ICB efficacy, showing their expansion and differentiation into tumor-infiltrating clonotypes.

Full-length single-cell BCR sequencing paired with RNA sequencing reveals convergent responses to vaccination

The paper develops a method to recover full-length BCR sequences from single-cell RNA libraries and applies it to study convergent B cell responses to vaccination in rhesus macaques.

Eradication of tumors with pre-existing antigenic heterogeneity by vaccine-mediated co-engagement of CAR T and endogenous T-cells

This study shows vaccine boosting of CAR T-cells enhances tumor eradication by promoting antigen spreading and endogenous T-cell engagement, even in antigen-negative tumors.

Identification of highly cross-reactive mimotopes for a public T cell response in murine melanoma

The paper identifies a dominant tumor-associated antigen in murine melanoma and shows that engineered mimotopes can induce cross-reactive T cell responses.

WAT3R: Recovery of T-Cell Receptor Variable Regions From 3' Single-Cell RNA-Sequencing

WAT3R recovers T-cell receptor variable regions from 3' scRNA-seq data, enabling T-cell clonotype reconstruction and analysis of TCR sequences in single cells.