Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition
Y. Li, V. K. Balakrishnan, M. Rowse…·Y. Xing
This study shows PME-1 demethylates PP2A holoenzymes and inhibits substrate recognition through structural interactions with the B56 subunit, revealing mechanisms of PME-1 activity and its role in p53 signaling.