A stress-function tradeoff organizes epithelial heterogeneity across spatial scales in the human thyroid
Yael Korem Kohanim, Tal Barkai, Roy Novoselsky, Sapir Shir, Keren Bahar Halpern, Shlomit Reich-Zeliger, Jacob Elkahal, Idit Tessler, Shaked Shivatzki, Ignat Schwartz, Eric Remer, Galit Avior, Rouven Hoefflin, Merav Kedmi, Hadas Keren‐Shaul, , Ruslan M. Medzhitov
The paper uses spatial transcriptomics to analyze thyroid heterogeneity, identifying a damage-response thyrocyte state that balances with hormone-producing states across scales.
bioRxiv · Mar 16, 2026 · PreprintSystems Biology