The ACE-inhibitor drug captopril inhibits ACN-1 to control dauer formation and aging
Brian M. Egan, Franziska Pohl, Xavier Anderson, Shoshana C. Williams, Imienreluefe Gregory Adodo, Patrick Hunt, Z Wang, Chen-Hao Chiu, Andrea Scharf, Matthew C. Mosley, Sandeep Kumar, Daniel L. Schneider, Hideji Fujiwara, Fong‐Fu Hsu, Kerry Kornfeld
The paper shows captopril extends lifespan in worms and mice by inhibiting ACN-1, which regulates dauer formation and interacts with daf genes.
Development · Jan 29, 2024Peer-reviewedDevelopmental Biology