Andrea Scharf

Diapause and Developmental Arrest as Drivers of Population Resilience Through Stress

This study examines how dauer formation and L1 arrest in C. elegans affect population resilience under stress, showing that daf-16 and daf-22 mutants have different recovery abilities and stage distributions compared to wild type.

Few-Shot Classification of C. elegans Developmental Stages via Explainable Hierarchical Hyperbolic Graph Embeddings

HyperDev uses hyperbolic geometry to classify C. elegans developmental stages with few labeled examples, achieving high accuracy and biological alignment.

Chaotic behavior influenced by an environmental parameter in simulated C. elegans populations

This study uses an agent-based model to simulate C. elegans populations and finds that chaotic dynamics emerge depending on culling parameters.

The ACE-inhibitor drug captopril inhibits ACN-1 to control dauer formation and aging

The paper shows captopril extends lifespan in worms and mice by inhibiting ACN-1, which regulates dauer formation and interacts with daf genes.

Pollutants corrupt resilience pathways of aging in the nematode C. elegans

This study shows that pollutants like silica nanoparticles and mercury reduce lifespan and cause premature protein aggregation in C. elegans by corrupting aging pathways.