Sphingolipid Biosynthesis Inhibition As A Host Strategy Against Diverse Pathogens
Sandeep Kumar, Jinmei Li, Jiwoong Park, Sydney K. Hart, Niki Song, Damon T. Burrow, Nicholas L. Bean, Nicholas C. Jacobs, Ariella L. G. Coler-Reilly, Anastasiia Onyshchenko, Tanya Hans Pierre, India C. Bradley, Jan E. Carette, Malini Varadarajan, Thijn R. Brummelkamp, , Timothy R. Peterson
This study identifies that multiple cationic amphipathic drugs (CADs) share molecular similarities with chloroquine and inhibit sphingolipid biosynthesis, suggesting their potential as antiviral agents against diverse pathogens including SARS-CoV-2.
bioRxiv · Apr 10, 2020 · PreprintGenomics