Author

Malini Varadarajan

ORCID 0000-0002-5271-8116Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:mouse· 1

Frequent Co-Authors

Damon T. BurrowiD· 2 shared Jan E. CaretteiD· 2 shared Jinmei LiiD· 2 shared Jiwoong ParkiD· 2 shared Niki SongiD· 2 shared Sandeep KumariD· 2 shared Thijn R. BrummelkampiD· 2 shared Timothy R. PetersoniD· 2 shared

Activity by Year

2020-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 44 mutual co-author links

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2 shared papersGenomics

Damon T. BurrowORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

ATRAID regulates the action of nitrogen-containing bisphosphonates on bone.

Lauren E. Surface, Damon T. Burrow, Jinmei Li, Jiwoong Park, Sandeep Kumar, Cheng Lyu, Niki Song, Zhou Yu, Abbhirami Rajagopal, Yangjin Bae, Brendan Lee, Steven R. Mumm, C. Charles Gu, Jonathan C. Baker, Mahshid Mohseni, , Timothy R. Peterson

The paper identifies ATRAID as a gene critical for the response to nitrogen-containing bisphosphonates, showing its role in drug efficacy and resistance in osteoporosis.

Science Translational Medicine · May 20, 2020Peer-reviewedGenomics

Sphingolipid Biosynthesis Inhibition As A Host Strategy Against Diverse Pathogens

Sandeep Kumar, Jinmei Li, Jiwoong Park, Sydney K. Hart, Niki Song, Damon T. Burrow, Nicholas L. Bean, Nicholas C. Jacobs, Ariella L. G. Coler-Reilly, Anastasiia Onyshchenko, Tanya Hans Pierre, India C. Bradley, Jan E. Carette, Malini Varadarajan, Thijn R. Brummelkamp, , Timothy R. Peterson

This study identifies that multiple cationic amphipathic drugs (CADs) share molecular similarities with chloroquine and inhibit sphingolipid biosynthesis, suggesting their potential as antiviral agents against diverse pathogens including SARS-CoV-2.

bioRxiv · Apr 10, 2020 · PreprintGenomics