Author

Nicholas L. Bean

Washington University in St. LouisORCID 0000-0002-4550-083XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 2 Organism:human· 2 Approach:experimental assay· 1 Approach:statistical model· 1

Frequent Co-Authors

Jinmei LiiD· 2 shared Jiwoong ParkiD· 2 shared Sandeep KumariD· 2 shared Tanya Hans PierreiD· 2 shared Timothy R. PetersoniD· 2 shared Anastasiia OnyshchenkoiD· 1 shared Ariella L. G. Coler-ReillyiD· 1 shared Brian N. FinckiD· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersGenomics

Jinmei LiORCID

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2 papers

Recent·Most cited

A dual MTOR/NAD+ acting gerotherapy

Jinmei Li, Sandeep Kumar, Kirill Miachin, Nicholas L. Bean, Ornella Halawi, Scott M. Lee, Jiwoong Park, Tanya Hans Pierre, Jin‐Hui Hor, Shi‐Yan Ng, K. Wallace, Niklas Rindtorff, Timothy M. Miller, Michael L. Niehoff, Susan A. Farr, , Timothy R. Peterson

This paper identifies BIOIO-1001 as a dual mTOR/NAD+ acting gerotherapy that reduces metabolic derangements, inflammation, and fibrosis in NASH and ALS models.

bioRxiv · Jan 16, 2023 · PreprintGenomics

Sphingolipid Biosynthesis Inhibition As A Host Strategy Against Diverse Pathogens

Sandeep Kumar, Jinmei Li, Jiwoong Park, Sydney K. Hart, Niki Song, Damon T. Burrow, Nicholas L. Bean, Nicholas C. Jacobs, Ariella L. G. Coler-Reilly, Anastasiia Onyshchenko, Tanya Hans Pierre, India C. Bradley, Jan E. Carette, Malini Varadarajan, Thijn R. Brummelkamp, , Timothy R. Peterson

This study identifies that multiple cationic amphipathic drugs (CADs) share molecular similarities with chloroquine and inhibit sphingolipid biosynthesis, suggesting their potential as antiviral agents against diverse pathogens including SARS-CoV-2.

bioRxiv · Apr 10, 2020 · PreprintGenomics