Isaac S. Lee

Meningococcal vaccine Bexsero elicits a robust cellular immune response that targets but is not consistently protective against Neisseria gonorrhoeae during murine vaginal infection

This study analyzes the immune response to Bexsero vaccine in mice, showing robust humoral and cellular responses but inconsistent protection against Neisseria gonorrhoeae.

Protection against Neisseria meningitidis nasopharyngeal colonization relies on antibody opsonization and phagocytosis by neutrophils

This study shows that antibodies and neutrophils, not complement, are critical for protecting against nasal colonization by Neisseria meningitidis.

Human transferrin and lactoferrin cooperatively support Neisseria meningitidis colonization in the murine nasopharynx

This study shows that human transferrin and lactoferrin, along with CEACAM1, support Neisseria meningitidis colonization in mice, with transferrin playing a critical role in sepsis and colonization.