Author

Laura-lee Caruso

University of TorontoORCID 0000-0002-4082-5408Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:mouse· 3 Approach:experimental assay· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1 Assay:flow cytometry· 1 Research Focus:host-pathogen & immune response· 1 Assay:protein structure· 1

Frequent Co-Authors

Epshita A. Islam· 3 shared Jamie E. Fegan· 3 shared Scott D. Gray‐OweniD· 3 shared Anthony Bernard SchryversiD· 2 shared Dixon NgiD· 2 shared Natalie Y.T. AuiD· 2 shared Trevor F. MoraesiD· 2 shared Carolyn M. Buckwalter· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersImmunology

Epshita A. Islam

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Rationally designed minimized TbpB confers broad protection against meningococcal infection

Epshita A. Islam, Jamie E. Fegan, Gregory B. Cole, Charles Calmettes, Dixon Ng, Natalie H. Au, Carolyn M. Buckwalter, Sang K. Ahn, David M. Curran, Laura-lee Caruso, Anthony Bernard Schryvers, Trevor F. Moraes, Scott D. Gray‐Owen

This paper designs a minimized TbpB protein to elicit broad protection against meningococcal strains by removing variable loops, showing superior cross-reactivity compared to full-length TbpB.

PLoS Pathogens · Aug 10, 2026Peer-reviewedImmunology

Structure-based engineering of a nutrient acquisition protein enhances neutralizing antibodies and protection for the development of a gonococcal vaccine

Natalie Y.T. Au, En Ze Linda Zhong-Johnson, Jamie E. Fegan, Epshita A. Islam, Stacey X. Xu, Dixon Ng, Megha K Shah, Laura-lee Caruso, Christine Chieh-Lin Lai, Anthony Bernard Schryvers, Scott D. Gray‐Owen, Trevor F. Moraes

This study engineered a gonococcal antigen to enhance vaccine effectiveness by reducing host factor binding while maintaining structure and immunogenicity.

bioRxiv · Nov 6, 2025 · PreprintImmunology

Meningococcal vaccine Bexsero elicits a robust cellular immune response that targets but is not consistently protective against Neisseria gonorrhoeae during murine vaginal infection

Joseph John Zeppa, Jamie E. Fegan, Pauline A Maiello, Epshita A. Islam, Isaac S. Lee, Christine Pham, Laura-lee Caruso, Scott D. Gray‐Owen

This study analyzes the immune response to Bexsero vaccine in mice, showing robust humoral and cellular responses but inconsistent protection against Neisseria gonorrhoeae.

mSphere · Apr 16, 2025Peer-reviewedImmunology