Anthony Bernard Schryvers

A loopless subdomain of transferrin binding protein B can elicit a broadly cross-reactive humoral immune response targeting variants from both encapsulated and non-typeable Haemophilus influenzae

This study identifies a loopless subdomain of TbpB that elicits broad cross-reactive antibodies against diverse H. influenzae strains.

Rationally designed minimized TbpB confers broad protection against meningococcal infection

This paper designs a minimized TbpB protein to elicit broad protection against meningococcal strains by removing variable loops, showing superior cross-reactivity compared to full-length TbpB.

Structure-based engineering of a nutrient acquisition protein enhances neutralizing antibodies and protection for the development of a gonococcal vaccine

This study engineered a gonococcal antigen to enhance vaccine effectiveness by reducing host factor binding while maintaining structure and immunogenicity.

Rational selection of TbpB variants elucidates a bivalent vaccine formulation with broad spectrum coverage against Neisseria gonorrhoeae

This study selects TbpB variants using phylogenetic analysis to create a bivalent vaccine formulation that elicits broad cross-reactive antibodies and shows efficacy against diverse gonococcal strains.

Human transferrin and lactoferrin cooperatively support Neisseria meningitidis colonization in the murine nasopharynx

This study shows that human transferrin and lactoferrin, along with CEACAM1, support Neisseria meningitidis colonization in mice, with transferrin playing a critical role in sepsis and colonization.