Scott D. Gray‐Owen

This paper designs a minimized TbpB protein to elicit broad protection against meningococcal strains by removing variable loops, showing superior cross-reactivity compared to full-length TbpB.

This study investigates the fitness benefits and costs of the H. pylori Cag-T4SS and CagA during stomach infection, showing initial benefits and later costs due to inflammation.

The paper investigates genetic and phenotypic differences between Neisseria gonorrhoeae strains causing disseminated gonococcal infections (DGI) and non-invasive strains in Canada, identifying two porB alleles and other genetic determinants associated with DGI.

This study engineered a gonococcal antigen to enhance vaccine effectiveness by reducing host factor binding while maintaining structure and immunogenicity.

This study analyzes the immune response to Bexsero vaccine in mice, showing robust humoral and cellular responses but inconsistent protection against Neisseria gonorrhoeae.

The paper analyzes 31,595 gonococcal genomes to identify genetic diversity, phase variability, and mobile elements linked to antimicrobial resistance and phenotypic traits.

This study selects TbpB variants using phylogenetic analysis to create a bivalent vaccine formulation that elicits broad cross-reactive antibodies and shows efficacy against diverse gonococcal strains.

This study evaluates adjuvant effects on vaccine-induced immunity against Neisseria species, showing adjuvant-dependent protection and no correlation between humoral response and protection.

This study shows that antibodies and neutrophils, not complement, are critical for protecting against nasal colonization by Neisseria meningitidis.

Navargator selects representative variants based on phylogenetic trees to improve cross-reactivity in vaccines, validated using immunization studies.

This study shows that human transferrin and lactoferrin, along with CEACAM1, support Neisseria meningitidis colonization in mice, with transferrin playing a critical role in sepsis and colonization.

The paper identifies ACE2 as the only common host dependency for SARS-CoV-2 across multiple cell lines, while other host factors are cell line specific.

The paper describes a multimerization platform that transforms antibodies into potent, broad-spectrum neutralizers against SARS-CoV-2.