Jamie E. Fegan

Rationally designed minimized TbpB confers broad protection against meningococcal infection

This paper designs a minimized TbpB protein to elicit broad protection against meningococcal strains by removing variable loops, showing superior cross-reactivity compared to full-length TbpB.

Structure-based engineering of a nutrient acquisition protein enhances neutralizing antibodies and protection for the development of a gonococcal vaccine

This study engineered a gonococcal antigen to enhance vaccine effectiveness by reducing host factor binding while maintaining structure and immunogenicity.

Meningococcal vaccine Bexsero elicits a robust cellular immune response that targets but is not consistently protective against Neisseria gonorrhoeae during murine vaginal infection

This study analyzes the immune response to Bexsero vaccine in mice, showing robust humoral and cellular responses but inconsistent protection against Neisseria gonorrhoeae.

Rational selection of TbpB variants elucidates a bivalent vaccine formulation with broad spectrum coverage against Neisseria gonorrhoeae

This study selects TbpB variants using phylogenetic analysis to create a bivalent vaccine formulation that elicits broad cross-reactive antibodies and shows efficacy against diverse gonococcal strains.

Adjuvant-dependent impacts on vaccine-induced humoral responses and protection in preclinical models of nasal and genital colonization by pathogenic Neisseria

This study evaluates adjuvant effects on vaccine-induced immunity against Neisseria species, showing adjuvant-dependent protection and no correlation between humoral response and protection.

Phylogeny-based selection of representative variants with Navargator: Proof of principle using humoral cross-reactivity data from two immunization studies

Navargator selects representative variants based on phylogenetic trees to improve cross-reactivity in vaccines, validated using immunization studies.

Human transferrin and lactoferrin cooperatively support Neisseria meningitidis colonization in the murine nasopharynx

This study shows that human transferrin and lactoferrin, along with CEACAM1, support Neisseria meningitidis colonization in mice, with transferrin playing a critical role in sepsis and colonization.