G-quadruplex ligand RHPS4 compromises cellular radio-resistance by blocking the increase in mitochondrial mass and activity induced by ionising irradiation.
Sabine Tricot, Capucine Siberchicot, Isaline Bontemps, Chantal Desmaze, Gueorgui Kratassiouk, Marie Vandamme, Guillaume Pinna, Ivan Nemazanyy, Juan Pablo Radicella, Guy Lenaers, Xavier Renaudin, Jérome Lebeau, Anna Campalans
This study shows that the G-quadruplex ligand RHPS4 reduces radioresistance by inhibiting mitochondrial adaptations caused by ionising irradiation.
NAR Cancer · Sep 11, 2025Peer-reviewedCell Biology