Molecular Basis and Cellular Effects of Janus-Class-Driven Cytoplasmic PYK2 Coacervates
Giovanni Colombo, Israa Salem, Kacper Szczepski, Piao Yu, Shaden Alfaiyz, Francisco J. Guzmán‐Vega, Ahmed Abogosh, Maxat Kulmanov, Samah Al-Harthi, Gress Kadaré, Robert Hoehndorf, Jean‐Antoine Girault, Łukasz Jaremko, Afaque A. Momin, Stefan T. Arold
This study identifies a novel mechanism of phase separation driven by the Janus-class KFL region of PYK2, showing its role in kinase activation and cell adhesion.
Communications Biology · Jan 9, 2026Peer-reviewedCell Biology