T. Shen

Resolving multi-image spatial lipidomic responses to inhaled toxicants by machine learning

The paper uses machine learning to analyze spatial lipidomic changes in mouse lungs exposed to allergens and ozone, revealing sex-specific lipid distribution differences.

The Class III peroxidase OsPrx20 is a key regulator of stress response and growth in rice

This study identifies OsPrx20 as a key regulator of stress response and growth in rice, showing its dual role in osmotic stress tolerance and blast resistance.

Risking your Tail: Modeling Individual Differences in Risk-sensitive Exploration using Bayes Adaptive Markov Decision Processes

This paper models individual differences in risk-sensitive exploration using a Bayes adaptive Markov decision process model applied to animal behavior data.

Node Features of Chromosome Structure Network and Their Connections to Genome Annotation

The paper investigates network properties of chromosome structure networks derived from Hi-C data and their connections to genome annotations, finding that semi-local properties better characterize biological features than local or diffusive features.

Evidence for peripheral and central actions of codeine to dysregulate deglutition in the anesthetized cat

This study investigates codeine's effects on swallowing in anesthetized cats, finding both central and peripheral mechanisms contributing to dysregulated swallowing.

Temporal and spatial staging of lung alveolar regeneration is determined by the grainyhead transcription factor Tfcp2l1

This study identifies Tfcp2l1 as a regulator of lung alveolar regeneration, balancing AT2 cell self-renewal and differentiation through spatial and temporal control.

Cardiac patch treatment alleviates ischemic cardiomyopathy correlated with reverting Piezo1/2 expression by unloading left ventricular myocardium

This study shows cardiac patches reduce ischemic cardiomyopathy by lowering mechanical load and reverting Piezo1/2 expression in the left ventricle.

Next generation of anti-PD-L1 Atezolizumab with better anti-tumor efficacy in vivo

This paper describes the development of a modified Atezolizumab (Maxatezo) with improved anti-tumor efficacy and reduced anti-drug antibody formation in vivo.

Oncogenic Activation of AKT by MAPK6

This study shows that MAPK6 activates AKT to promote cancer, leading to oncogenic outcomes and poor patient survival in multiple cancers.

A Uropathogenic E. coli UTI89 model of prostatic inflammation and collagen accumulation for use in studying aberrant collagen production in the prostate

This paper develops a mouse model of prostatic inflammation and collagen accumulation using E. coli UTI89 instillations to study aberrant collagen production in the prostate.

Identification of a novel tedizolid resistance mutation in rpoB of methicillin-resistant Staphylococcus aureus

The paper identifies a novel rpoB mutation in MRSA associated with tedizolid resistance and reports cross-resistance to other antibiotics.

Occurrence of cross-resistance and beta-lactam seesaw effect in glycopeptide, lipopeptide, and lipoglycopeptide-resistant MRSA correlates with membrane phosphatidylglycerol levels

The paper investigates the relationship between membrane phosphatidylglycerol levels and cross-resistance, as well as the beta-lactam seesaw effect, in MRSA strains resistant to glycopeptides, lipopeptides, and lipoglycopeptides.

Characterizing the 3D structure and dynamics of chromosomes and proteins in a common contact matrix framework

This paper compares E-PCA and I-PCA methods on chromosome and protein contact matrices to reveal structural dynamics and differences across cell types and protein complexes.