Author

J. A. Hoxie

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:non-human primate· 3 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1

Frequent Co-Authors

F. Schiro· 3 shared L. A. Doyle-Meyers· 3 shared N. J. Maness· 3 shared P. P. Aye· 3 shared R. V. Blair· 3 shared A. Melton· 2 shared B. J. Beddingfield· 2 shared D. Szeltner· 2 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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3 shared papersImmunology

F. Schiro

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

The Impact of SIV-Induced Immunodeficiency on Clinical Manifestation, Immune Response, and Viral Dynamics in SARS-CoV-2 Coinfection

A. Melton, L. A. Rowe, T. Penney, C. Krzykwa, K. Goff, S. E. Scheuermann, H. J. Melton, K. Williams, N. Golden, K. Moore Green, B. Smith, K. Russell-Lodrigue, J. P. Dufour, L. A. Doyle-Meyers, F. Schiro, , N. J. Maness

This study examines how SIV-induced immunodeficiency affects SARS-CoV-2 infection in macaques, finding that while immune responses are impaired, viral kinetics and evolution remain unchanged.

bioRxiv · Nov 15, 2023 · PreprintImmunology

The pigtail macaque (Macaca nemestrina) model of COVID-19 reproduces diverse clinical outcomes and reveals new and complex signatures of disease

A. Melton, L. A. Doyle-Meyers, R. V. Blair, C. Midkiff, H. J. Melton, K. Russell-Lodrigue, P. P. Aye, F. Schiro, M. Fahlberg, D. Szeltner, S. Spencer, B. J. Beddingfield, K. Goff, N. Golden, T. Penney, , N. J. Maness

This study shows that pigtail macaques infected with SARS-CoV-2 exhibit mild-to-moderate disease with specific immune and viral dynamics, making them a potential model for studying COVID-19.

bioRxiv · Aug 28, 2021Immunology

A tyrosine-based trafficking signal in the simian immunodeficiency virus envelope cytoplasmic domain is strongly selected for in pathogenic SIV infection

S. Lawrence, S. E. Elser, W. Torben, R. V. Blair, B. Pahar, P. P. Aye, F. Schiro, D. Szeltner, L. A. Doyle-Meyers, B. Haggarty, A. O. Jordan, J. Romano, X. Alvarez, D. H. O'Connor, R. W. Wiseman, , J. A. Hoxie

This study shows that a tyrosine-based trafficking signal in SIV Env is strongly selected for during pathogenic infection, as mutations reconstitute endocytosis and polarized sorting signals.

bioRxiv · Mar 31, 2021 · PreprintCell Biology