N. J. Maness

The Impact of SIV-Induced Immunodeficiency on Clinical Manifestation, Immune Response, and Viral Dynamics in SARS-CoV-2 Coinfection

This study examines how SIV-induced immunodeficiency affects SARS-CoV-2 infection in macaques, finding that while immune responses are impaired, viral kinetics and evolution remain unchanged.

Real time analysis of SARS-CoV-2 induced cytolysis reveals distinct variant-specific replication profiles

This study uses real-time cell analysis to compare replication kinetics of SARS-CoV-2 variants, finding distinct replication profiles among WA1/2020, Delta, and Omicron subvariants.

Durable protection against SARS-CoV-2 Omicron induced by an adjuvanted subunit vaccine

This study shows that an adjuvanted subunit vaccine provides durable protection against SARS-CoV-2 Omicron in non-human primates, with strong neutralizing antibodies and memory T/B cells after booster doses.

Myeloid cell-driven nonregenerative pulmonary scarring is conserved in multiple nonhuman primate species regardless of SARS-CoV-2 infection modality

This study shows that nonhuman primates develop similar pulmonary scarring regardless of SARS-CoV-2 infection route, suggesting conserved disease mechanisms.

The pigtail macaque (Macaca nemestrina) model of COVID-19 reproduces diverse clinical outcomes and reveals new and complex signatures of disease

This study shows that pigtail macaques infected with SARS-CoV-2 exhibit mild-to-moderate disease with specific immune and viral dynamics, making them a potential model for studying COVID-19.

Intra-host SARS-CoV-2 evolution in the gut of mucosally-infected Chlorocebus aethiops (African green monkeys)

This study tracks SARS-CoV-2 evolution in African green monkeys after respiratory infection, identifying mutations lost in vivo and host-adapted variants.

Effective prophylaxis of COVID-19 in rhesus macaques using a combination of two parentally-administered SARS-CoV-2 neutralizing antibodies

This study shows that a combination of two SARS-CoV-2 neutralizing antibodies prevents COVID-19 in rhesus macaques, with full protection at a higher dose and partial protection at lower doses.

A tyrosine-based trafficking signal in the simian immunodeficiency virus envelope cytoplasmic domain is strongly selected for in pathogenic SIV infection

This study shows that a tyrosine-based trafficking signal in SIV Env is strongly selected for during pathogenic infection, as mutations reconstitute endocytosis and polarized sorting signals.

Adjuvanting a subunit SARS-CoV-2 nanoparticle vaccine to induce protective immunity in non-human primates

This study evaluates adjuvants for a subunit SARS-CoV-2 nanoparticle vaccine in non-human primates, showing durable neutralizing antibody responses and protection against infection.

Cellular events of acute, resolving or progressive COVID-19 in SARS-CoV-2 infected non-human primates

This study examines immune events in non-human primates infected with SARS-CoV-2, identifying cellular correlates of disease severity and potential therapeutic targets.

Acute Respiratory Distress and Cytokine Storm in Aged, SARS-CoV-2 Infected African Green Monkeys, but not in Rhesus Macaques

This study compares SARS-CoV-2 infection in aged African green monkeys and rhesus macaques, finding ARDS and cytokine storms in AGMs but not RMs.

Zika virus infection during pregnancy protects against secondary infection in the absence of CD8+ cells

This study shows that ZIKV infection during pregnancy provides protection against secondary infection without relying on CD8+ cells.

A Zika Virus Primary Isolate Induces Neuroinflammation, Compromises the Blood-Brain Barrier, and Upregulates CXCL12 in Adult Macaques

This study investigates ZIKV-induced neuropathy in adult macaques, finding chronic neuroinflammation, BBB disruption, and sustained CXCL12 upregulation in the CNS.

Brief report: Mutations in SIV Nef that disrupt and restore tetherin downregulation

The paper identifies a mutation in SIV Nef that disrupts tetherin downregulation and shows that an upstream residue can restore this function.

CD8+ lymphocytes modulate Zika virus dynamics and tissue dissemination and orchestrate antiviral immunity

This study shows CD8+ lymphocytes control ZIKV dissemination and immune regulation in nonhuman primates by affecting viremia, tissue viral loads, and immune responses.