Author

A. Melton

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 2 Microbiology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:non-human primate· 3 Assay:bulk RNA-seq· 2 Research Focus:differential expression· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Organism:human· 1

Frequent Co-Authors

B. J. Beddingfield· 3 shared K. Goff· 3 shared N. J. Maness· 3 shared C. J. Roy· 2 shared F. Schiro· 2 shared H. J. Melton· 2 shared J. A. Hoxie· 2 shared J. Rappaport· 2 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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Curved chords = mutual co-authorship

3 shared papersImmunology

B. J. Beddingfield

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The Impact of SIV-Induced Immunodeficiency on Clinical Manifestation, Immune Response, and Viral Dynamics in SARS-CoV-2 Coinfection

A. Melton, L. A. Rowe, T. Penney, C. Krzykwa, K. Goff, S. E. Scheuermann, H. J. Melton, K. Williams, N. Golden, K. Moore Green, B. Smith, K. Russell-Lodrigue, J. P. Dufour, L. A. Doyle-Meyers, F. Schiro, , N. J. Maness

This study examines how SIV-induced immunodeficiency affects SARS-CoV-2 infection in macaques, finding that while immune responses are impaired, viral kinetics and evolution remain unchanged.

bioRxiv · Nov 15, 2023 · PreprintImmunology

The pigtail macaque (Macaca nemestrina) model of COVID-19 reproduces diverse clinical outcomes and reveals new and complex signatures of disease

A. Melton, L. A. Doyle-Meyers, R. V. Blair, C. Midkiff, H. J. Melton, K. Russell-Lodrigue, P. P. Aye, F. Schiro, M. Fahlberg, D. Szeltner, S. Spencer, B. J. Beddingfield, K. Goff, N. Golden, T. Penney, , N. J. Maness

This study shows that pigtail macaques infected with SARS-CoV-2 exhibit mild-to-moderate disease with specific immune and viral dynamics, making them a potential model for studying COVID-19.

bioRxiv · Aug 28, 2021Immunology

Intra-host SARS-CoV-2 evolution in the gut of mucosally-infected Chlorocebus aethiops (African green monkeys)

L. A. Rowe, B. J. Beddingfield, K. Goff, S. Z. Killeen, N. R. Chirichella, A. Melton, C. J. ROY, N. J. Maness

This study tracks SARS-CoV-2 evolution in African green monkeys after respiratory infection, identifying mutations lost in vivo and host-adapted variants.

bioRxiv · Aug 22, 2021Microbiology

Pulmonary Metagenomic Sequencing Suggests Missed Infections in Immunocompromised Children

M. S. Zinter, C. C. Dvorak, M. Y. Mayday, K. Iwanaga, N. P. Ly, M. E. McGarry, G. D. Church, L. E. Faricy, C. M. Rowan, J. R. Hume, M. E. Steiner, E. D. Crawford, C. Langelier, K. Kalantar, E. D. Chow, , J. L. DeRisi

This study develops a metagenomic sequencing assay to detect missed pathogens in immunocompromised children, finding increased sensitivity for identifying potential pathogens in lung samples.

bioRxiv · Mar 29, 2018Microbiology