Author

B. J. Beddingfield

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 8 Research Focus:host-pathogen & immune response· 8 Organism:non-human primate· 6 Assay:bulk RNA-seq· 3 Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Research Focus:cell-cell communication· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

N. J. Maness· 7 shared C. J. Roy· 5 shared J. Rappaport· 4 shared K. Goff· 4 shared L. A. Doyle-Meyers· 4 shared N. Golden· 4 shared P. P. Aye· 4 shared R. V. Blair· 4 shared

Activity by Year

2021-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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7 shared papersMicrobiology

N. J. Maness

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

The Impact of SIV-Induced Immunodeficiency on Clinical Manifestation, Immune Response, and Viral Dynamics in SARS-CoV-2 Coinfection

A. Melton, L. A. Rowe, T. Penney, C. Krzykwa, K. Goff, S. E. Scheuermann, H. J. Melton, K. Williams, N. Golden, K. Moore Green, B. Smith, K. Russell-Lodrigue, J. P. Dufour, L. A. Doyle-Meyers, F. Schiro, , N. J. Maness

This study examines how SIV-induced immunodeficiency affects SARS-CoV-2 infection in macaques, finding that while immune responses are impaired, viral kinetics and evolution remain unchanged.

bioRxiv · Nov 15, 2023 · PreprintImmunology

Real time analysis of SARS-CoV-2 induced cytolysis reveals distinct variant-specific replication profiles

S. E. Scheuermann, K. A. Goff, L. A. Rowe, B. J. Beddingfield, N. J. Maness

This study uses real-time cell analysis to compare replication kinetics of SARS-CoV-2 variants, finding distinct replication profiles among WA1/2020, Delta, and Omicron subvariants.

bioRxiv · Mar 28, 2023 · PreprintMicrobiology

Durable protection against SARS-CoV-2 Omicron induced by an adjuvanted subunit vaccine

P. S. Arunachalam, Y. Feng, U. Ashraf, M. Hu, V. V. Edara, V. I. Zarnitsyna, P. P. Aye, N. Golden, K. W. M. Green, B. M. Threeton, N. J. Maness, B. J. Beddingfield, R. P. Bohm, J. Dufour, K. Russell-Lodrigue, , B. Pulendran

This study shows that an adjuvanted subunit vaccine provides durable protection against SARS-CoV-2 Omicron in non-human primates, with strong neutralizing antibodies and memory T/B cells after booster doses.

bioRxiv · Mar 18, 2022 · PreprintImmunology

Myeloid cell-driven nonregenerative pulmonary scarring is conserved in multiple nonhuman primate species regardless of SARS-CoV-2 infection modality

A. C. Fears, B. J. Beddingfield, N. R. Chirichella, N. Slisarenko, S. Z. Killeen, R. K. Redmann, K. Goff, S. Spencer, B. Picou, N. Golden, D. J. Bush, L. M. Branco, M. L. Boisen, H. Gao, D. Montefiori, , C. J. Roy

This study shows that nonhuman primates develop similar pulmonary scarring regardless of SARS-CoV-2 infection route, suggesting conserved disease mechanisms.

bioRxiv · Nov 28, 2021 · PreprintMicrobiology

The pigtail macaque (Macaca nemestrina) model of COVID-19 reproduces diverse clinical outcomes and reveals new and complex signatures of disease

A. Melton, L. A. Doyle-Meyers, R. V. Blair, C. Midkiff, H. J. Melton, K. Russell-Lodrigue, P. P. Aye, F. Schiro, M. Fahlberg, D. Szeltner, S. Spencer, B. J. Beddingfield, K. Goff, N. Golden, T. Penney, , N. J. Maness

This study shows that pigtail macaques infected with SARS-CoV-2 exhibit mild-to-moderate disease with specific immune and viral dynamics, making them a potential model for studying COVID-19.

bioRxiv · Aug 28, 2021Immunology

Intra-host SARS-CoV-2 evolution in the gut of mucosally-infected Chlorocebus aethiops (African green monkeys)

L. A. Rowe, B. J. Beddingfield, K. Goff, S. Z. Killeen, N. R. Chirichella, A. Melton, C. J. ROY, N. J. Maness

This study tracks SARS-CoV-2 evolution in African green monkeys after respiratory infection, identifying mutations lost in vivo and host-adapted variants.

bioRxiv · Aug 22, 2021Microbiology

Effective prophylaxis of COVID-19 in rhesus macaques using a combination of two parentally-administered SARS-CoV-2 neutralizing antibodies

B. J. Beddingfield, N. J. Maness, A. C. Fears, J. Rappaport, P. P. Aye, K. E. Russell-Lodrigue, L. A. Doyle-Meyers, R. V. Blair, A. M. Carias, R. L. Redondo, P. J. Madden, H. Gao, D. Montefiori, T. J. Hope, C. J. ROY

This study shows that a combination of two SARS-CoV-2 neutralizing antibodies prevents COVID-19 in rhesus macaques, with full protection at a higher dose and partial protection at lower doses.

bioRxiv · May 26, 2021Microbiology

Phenotypic and Kinetic Changes of Myeloid Lineage Cells in Innate Response to Chikungunya Infection in Cynomolgus Macaques

B. J. Beddingfield, C. Sugimoto, M. J. Kuroda, E. Wang, S. C. Weaver, K. E. Russell-Lodrigue, S. Z. Killeen, C. J. ROY

This study examines kinetic and phenotypic changes in myeloid lineage cells during early Chikungunya infection in cynomolgus macaques, revealing altered cell turnover and activation states.

bioRxiv · May 18, 2021Immunology