Author

J. A. Mitchel

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1 Assay:imaging· 1

Frequent Co-Authors

J. P. Butler· 3 shared J.-A. Park· 3 shared C. Y. Park· 2 shared J. J. Fredberg· 2 shared M. J. O'Sullivan· 2 shared S. J. DeCamp· 2 shared S. Koehler· 2 shared A. Das· 1 shared

Activity by Year

2018-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersBiophysics

J. P. Butler

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4 papers

Recent·Most cited

In airway epithelium, basal stem cells and their stress fibers remodel during the unjamming transition

T.-K. N. Phung, J. A. Mitchel, M. J. O'Sullivan, J.-A. Park

The paper identifies structural changes in basal stem cells during an unjamming transition in airway epithelium, suggesting they generate traction forces for collective migration.

bioRxiv · Aug 18, 2022 · PreprintCell Biology

Epithelial layer unjamming shifts energy metabolism toward glycolysis

S. J. DeCamp, V. M. K. Tsuda, J. Ferruzzi, S. A. Koehler, D. Roblyer, J. T. Giblin, M. H. Zaman, S. T. Weiss, M. DeMarzio, C. Y. Park, N. C. Ogassavara, J. A. Mitchel, J. P. Butler, J. J. Fredberg

The paper shows that during epithelial layer unjamming, cells shift their metabolism toward glycolysis, even in regions without visible morphological changes.

bioRxiv · Jun 30, 2020Biophysics

The unjamming transition is distinct from the epithelial-to-mesenchymal transition.

J. A. Mitchel, A. Das, M. J. O'Sullivan, I. T. Stancil, S. J. DeCamp, S. Koehler, J. P. Butler, J. J. Fredberg, M. A. Nieto, D. Bi, J.-A. Park

This paper distinguishes the unjamming transition (UJT) from the epithelial-to-mesenchymal transition (EMT) by showing UJT enables collective epithelial migration without EMT features.

bioRxiv · Jun 10, 2019 · PreprintBiophysics

The tumor suppressor p53 promotes carcinoma invasion and collective cellular migration

S. HE, C. V. Carman, J. H. Lee, B. Lan, S. Koehler, L. Atia, C. Y. Park, J. H. Kim, J. A. Mitchel, J.-A. Park, J. P. Butler, S. W. Lee, J. Fredberg

This study shows that p53 loss decreases single-cell motility and invasion in 2-D and 3-D assays, but promotes collective cellular migration in spheroids.

bioRxiv · Jul 30, 2018Cancer Biology