Author

J. P. Butler

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

J. A. Mitchel· 3 shared J. J. Fredberg· 3 shared S. Koehler· 3 shared C. Y. Park· 2 shared D. Roblyer· 2 shared J. Ferruzzi· 2 shared J.-A. Park· 2 shared M. H. Zaman· 2 shared

Activity by Year

2018-2020 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersBiophysics

J. A. Mitchel

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Epithelial layer unjamming shifts energy metabolism toward glycolysis

S. J. DeCamp, V. M. K. Tsuda, J. Ferruzzi, S. A. Koehler, D. Roblyer, J. T. Giblin, M. H. Zaman, S. T. Weiss, M. DeMarzio, C. Y. Park, N. C. Ogassavara, J. A. Mitchel, J. P. Butler, J. J. Fredberg

The paper shows that during epithelial layer unjamming, cells shift their metabolism toward glycolysis, even in regions without visible morphological changes.

bioRxiv · Jun 30, 2020Biophysics

Tumor invasion as non-equilibrium phase separation

W. Kang, J. Ferruzzi, C.-P. Spatarelu, Y. L. Han, Y. Sharma, S. Koehler, J. P. Butler, D. Roblyer, M. H. Zaman, M. Guo, Z. Chen, A. F. Pegoraro, J. J. Fredberg

The paper shows tumor spheroids exhibit solid-like, fluid-like, and gas-like phases during invasion, with phase transitions influenced by cell type and matrix density.

bioRxiv · Apr 28, 2020 · PreprintBiophysics

The unjamming transition is distinct from the epithelial-to-mesenchymal transition.

J. A. Mitchel, A. Das, M. J. O'Sullivan, I. T. Stancil, S. J. DeCamp, S. Koehler, J. P. Butler, J. J. Fredberg, M. A. Nieto, D. Bi, J.-A. Park

This paper distinguishes the unjamming transition (UJT) from the epithelial-to-mesenchymal transition (EMT) by showing UJT enables collective epithelial migration without EMT features.

bioRxiv · Jun 10, 2019 · PreprintBiophysics

The tumor suppressor p53 promotes carcinoma invasion and collective cellular migration

S. HE, C. V. Carman, J. H. Lee, B. Lan, S. Koehler, L. Atia, C. Y. Park, J. H. Kim, J. A. Mitchel, J.-A. Park, J. P. Butler, S. W. Lee, J. Fredberg

This study shows that p53 loss decreases single-cell motility and invasion in 2-D and 3-D assays, but promotes collective cellular migration in spheroids.

bioRxiv · Jul 30, 2018Cancer Biology