Author

J. A. Shupe

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 1 Pathology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:host-pathogen & immune response· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Assay:imaging· 1

Frequent Co-Authors

D. B. Lacy· 3 shared F. C. Peritore-Galve· 2 shared M. K. Washington· 2 shared A. Smith· 1 shared E. N. Laubacher· 1 shared I. Kaji· 1 shared J. R. Goldenring· 1 shared L. M. Walker· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

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3 shared papersPhysiology

D. B. Lacy

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Toxin-mediated downregulation of absorptive ion transporters NHE3, DRA, and SGLT1 in the colon contributes to diarrhea associated with Clostridioides difficile infection.

F. C. Peritore-Galve, I. Kaji, A. Smith, L. M. Walker, J. A. Shupe, P. K. Dudeja, J. R. Goldenring, D. B. Lacy

This study shows CDI reduces NHE3, DRA, and SGLT1 in the colon, impairing ion transport and causing osmotic diarrhea.

bioRxiv · Nov 12, 2022 · PreprintPhysiology

Glucosyltransferase-dependent and independent effects of Clostridioides difficile toxins during infection

F. C. Peritore-Galve, J. A. Shupe, R. J. Cave, M. K. Washington, S. A. Kuehne, D. B. Lacy

This study investigates the role of glucosyltransferase-dependent and independent effects of Clostridioides difficile toxins TcdA and TcdB during infection, showing both contribute to disease with distinct pathological outcomes.

PLOS Pathogens · Feb 17, 2022Peer-reviewedPathology

Murine intrarectal instillation of purified recombinant C. difficile toxins enables mechanistic studies of pathogenesis

N. O. Markham, S. C. Bloch, J. A. Shupe, E. N. Laubacher, M. K. Washington, R. J. Coffey, D. B. Lacy

This study uses purified recombinant C. difficile toxins in a mouse model to investigate their pathogenic mechanisms and tissue effects.

bioRxiv · Aug 30, 2020Microbiology