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Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.
18 papers
Recent·Most cited
F. Jian, A. Z. Wec, L. Feng, Y. Yu, L. Wang, P. Wang, L. Yu, J. Wang, J. Hou, D. M. Berrueta, D. Lee, T. Speidel, L. Ma, T. Kim, A. Yisimayi, , Y. Cao
This paper predicts SARS-CoV-2 RBD evolution using deep mutational scanning to identify broadly neutralizing antibodies effective against existing and prospective variants.
bioRxiv · Apr 16, 2024Immunology
O. S. Shin, S. R. Monticelli, C. K. Hjorth, V. Hornet, M. Doyle, D. Abelson, A. I. Kuehne, A. Wang, R. R. Bakken, A. K. Mishra, M. Middlecamp, E. Champney, L. Stuart, D. P. Maurer, J. Li, , J. S. McLellan
The paper identifies non-neutralizing antibodies from CCHFV survivors that target multiple regions on GP38, showing protective efficacy in rodent models.
bioRxiv · Mar 2, 2024Immunology
R. I. Connor, M. I. Sakharkar, C. G. Rappazzo, C. I. Kaku, N. C. Curtis, S. Shin, W. F. Wieland-Alter, J. A. Weiner, M. E. Ackerman, L. M. Walker, J. Lee, P. F. Wright
This study identifies infection-enhancing antibodies targeting the N-terminal domain of SARS-CoV-2 spike protein, which persist in convalescent patients and may be counteracted by viral mutations.
bioRxiv · Sep 19, 2023Immunology
N. C. Curtis, S. Shin, A. P. Hederman, R. I. Connor, W. F. Wieland-Alter, S. Ionov, J. Boylston, J. Rose, M. Sakharkar, D. B. Dorman, J. A. Dessaint, L. L. Gwilt, A. R. Crowley, J. Feldman, B. M. Hauser, , J. Lee
This study characterizes the serological repertoire of SARS-CoV-2 convalescent patients, revealing a high prevalence of iso-RBD antibodies that do not recognize prefusion-stabilized S, and shows that vaccination with prefusion-stabilized S reduces their prevalence.
bioRxiv · Sep 8, 2023 · PreprintImmunology
F. C. Peritore-Galve, I. Kaji, A. Smith, L. M. Walker, J. A. Shupe, P. K. Dudeja, J. R. Goldenring, D. B. Lacy
This study shows CDI reduces NHE3, DRA, and SGLT1 in the colon, impairing ion transport and causing osmotic diarrhea.
bioRxiv · Nov 12, 2022 · PreprintPhysiology
L. M. Walker, R. N. Sherpa, S. Ivaturi, D. A. Brock, J. R. Walker, J. E. Strassmann, D. C. Queller
The paper identifies genomic changes in Dictyostelium discoideum that correlate with the loss of cooperation and altruism, highlighting the role of the grlG gene.
bioRxiv · Oct 21, 2022Evolutionary Biology
C. I. Kaku, T. N. Starr, P. Zhou, H. L. Dugan, P. Khalife, G. Song, E. R. Champney, D. W. Mielcarz, J. C. Geoghegan, D. R. Burton, R. Andrabi, J. D. Bloom, L. M. Walker
This study tracks antibody responses six months after Omicron BA.1 breakthrough infection and finds reduced neutralizing antibodies and memory B cells, with public clones dominating and predicting new sublineages.
bioRxiv · Sep 21, 2022 · PreprintImmunology
M. J. Ricciardi, L. N. Rust, N. Pedreno-Lopez, S. Yusova, S. Biswas, G. M. Webb, M. Fischer, L. Gonsales-Nieto, T. B. Voigt, J. J. Louw, F. D. Laurino, J. R. DiBello, H.-P. Raue, L. M. S. Raphael, A. Yrizarry-Medina, , B. J. Burwitz
Therapeutic monoclonal antibodies prevent death from YFV infection.
bioRxiv · May 16, 2022 · PreprintImmunology
C. I. Kaku, A. J. Bergeron, C. Ahlm, J. Normark, M. Sakharkar, M. N. Forsell, L. M. Walker
BA.1 breakthrough infection activates pre-existing memory B cells with broad activity against SARS-CoV-2 variants.
bioRxiv · Apr 1, 2022 · PreprintImmunology
M. Yuan, X. Zhu, W.-t. He, P. Zhou, C. I. Kaku, T. Capozzola, C. Y. Zhu, X. Yu, H. Liu, W. Yu, Y. Hua, H. Tien, L. Peng, G. Song, C. Cottrell, , I. A. Wilson
The paper identifies a broadly neutralizing epitope in SARS-related coronaviruses that is effective against variants, including Omicron, and suggests its use for universal vaccine design.
bioRxiv · Mar 13, 2022 · PreprintMicrobiology
H. Liu, C. I. Kaku, G. Song, M. Yuan, R. Andrabi, D. R. Burton, L. M. Walker, I. A. Wilson
The paper identifies a YYDRxG motif in antibodies that broadly neutralize SARS-CoV-2 variants and related viruses, suggesting a conserved epitope targeting strategy.
bioRxiv · Dec 15, 2021 · PreprintImmunology
D. Haslwanter, G. Lasso, A. Z. Wec, N. D. Furtado, L. M. S. Raphael, Y. Sun, S. Stransky, N. Pedreno-Lopez, A. Tse, C. A. Correia, Z. A. Bornholdt, M. Sakharkar, V. I. Avelino-Silva, C. L. Moyer, D. I. Watkins, , K. Chandran
This study shows that South American yellow fever virus strains are less susceptible to vaccine-induced antibodies due to genetic changes in the glycoprotein E.
bioRxiv · Aug 22, 2021Microbiology
K. J. Kramer, E. M. Wilfong, K. Voss, S. Barone, A. R. Shiakolas, N. Raju, C. E. Roe, N. Suryadevara, L. M. Walker, S. C. Wall, A. Paulo, S. Schaefer, D. Dahunsi, C. S. Westlake, J. E. Crowe, , J. M. Irish
bioRxiv · Jul 28, 2021Immunology
C. G. Rappazzo, L. V. Tse, C. I. Kaku, D. Wrapp, M. Sakharkar, D. Huang, L. M. Deveau, T. J. Yockachonis, A. S. Herbert, M. B. Battles, C. M. O'Brien, M. E. Brown, J. C. Geoghegan, J. Belk, L. Peng, , L. M. Walker
This study engineers an antibody, ADG-2, that broadly neutralizes SARS-CoV and SARS-CoV-2 in mice, offering protection against respiratory disease and viral replication.
bioRxiv · Nov 17, 2020 · PreprintImmunology
A. Z. Wec, D. Wrapp, A. S. Herbert, D. P. Maurer, D. Haslwanter, M. Sakharkar, R. K. Jangra, M. E. Dieterle, A. Lilov, D. Huang, L. V. Tse, N. V. Johnson, C.-L. Hsieh, N. Wang, J. H. Nett, , L. M. Walker
The paper identifies broadly neutralizing antibodies against SARS-CoV-2 and related sarbecoviruses, highlighting a conserved epitope on the spike protein as a potential vaccine target.
bioRxiv · May 15, 2020 · PreprintImmunology
A. Z. Wec, Z. A. Bornholdt, S. He, A. S. Herbert, E. Goodwin, A. S. Wirchnianski, B. M. Gunn, Z. Zhang, W. Zhu, G. Liu, D. M. Abelson, C. L. Moyer, R. K. Jangra, R. M. James, R. R. Bakken, , K. Chandran
This paper develops a human antibody cocktail, MBP134, that provides broad protection against multiple ebolaviruses, showing enhanced efficacy in guinea pigs compared to individual antibodies.
bioRxiv · Aug 20, 2018Microbiology
Z. A. Bornholdt, A. S. Herbert, C. E. Mire, S. He, R. W. Cross, A. Z. Wec, D. M. Abelson, J. B. Geisbert, R. M. James, M. N. Rahim, W. Zhu, V. Borisevich, L. Banadyga, B. M. Gunn, K. N. Agans, , J. M. Dye
This paper demonstrates that a two-antibody cocktail (MBP134AF) provides broad therapeutic protection against multiple ebolaviruses in ferrets and nonhuman primates.
bioRxiv · Aug 19, 2018Microbiology
B. R. West, A. Z. Wec, C. L. Moyer, M. L. Fusco, P. A. Illinykh, K. Huang, R. James, A. Herbert, S. Hui, A. S. Wirchnianski, E. Goodwin, M. J. Aman, L. M. Walker, J. M. Dye, A. Bukreyev, , E. O. Saphire
The paper determines the structure of a broadly neutralizing antibody against ebolavirus, identifies a conserved epitope, and explains factors affecting its activity against related viruses.
bioRxiv · Aug 19, 2018Immunology