Author

N. O. Markham

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 2 Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell type annotation· 2 Research Focus:host-pathogen & immune response· 2 Assay:imaging· 2 Organism:mouse· 2 Assay:spatial transcriptomics· 2 Research Focus:cell-cell communication· 1

Frequent Co-Authors

R. J. Coffey· 4 shared M. K. Washington· 3 shared A. J. Simmons· 2 shared C. L. Sears· 2 shared D. B. Lacy· 2 shared J. A. Shupe· 2 shared J. T. Roland· 2 shared M. J. Shrubsole· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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4 shared papersMicrobiology

R. J. Coffey

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Author profile →

4 papers

Recent·Most cited

Inhibition of EGFR/ErbB does not protect against C. difficile toxin B

U. Siddiqi, H. M. Lunnemann, K. O. Childress, J. A. Shupe, S. A. Rutherford, M. A. Farrow, M. K. Washington, R. J. Coffey, D. B. Lacy, N. O. Markham

This study investigates whether inhibiting EGFR/ErbB receptors protects against C. difficile toxin B, finding no protective effect.

bioRxiv · May 13, 2024 · PreprintMicrobiology

Human colorectal pre-cancer atlas identifies distinct molecular programs underlying two major subclasses of pre-malignant tumors

B. Chen, E. T. McKinley, A. J. Simmons, M. A. Ramirez, X. Zhu, A. N. Southard-Smith, N. O. Markham, Q. Sheng, J. Drewes, Y. Xu, C. N. Heiser, Y. Zhou, F. Revetta, L. D. Berry, W. Zheng, , K. Lau

The paper creates a single-cell atlas of colorectal pre-cancerous polyps, identifying distinct molecular programs in adenomas and sessile serrated lesions and their associations with CRC subtypes.

bioRxiv · Jan 11, 2021Cancer Biology

Murine intrarectal instillation of purified recombinant C. difficile toxins enables mechanistic studies of pathogenesis

N. O. Markham, S. C. Bloch, J. A. Shupe, E. N. Laubacher, M. K. Washington, R. J. Coffey, D. B. Lacy

This study uses purified recombinant C. difficile toxins in a mouse model to investigate their pathogenic mechanisms and tissue effects.

bioRxiv · Aug 30, 2020Microbiology

Clinically adaptable polymer enables simultaneous spatial analysis of colonic tissues and biofilms

M. C. Macedonia, J. L. Drewes, N. O. Markham, A. J. Simmons, J. T. Roland, P. N. Vega, C. R. Scurrah, R. J. Coffey, M. J. Shrubsole, C. L. Sears, K. S. Lau

This paper introduces a clinically adaptable polymer that preserves spatial compartments of colonic tissues and biofilms for simultaneous analysis.

bioRxiv · Apr 15, 2020Cell Biology