P. Tsvetkov

FDX1 regulates cellular protein lipoylation through direct binding to LIAS.

This study identifies FDX1 as a direct regulator of protein lipoylation by binding to LIAS, essential for cell survival under low glucose conditions.

In silico molecular target prediction unveils mebendazole as a potent MAPK14 inhibitor

This paper identifies mebendazole as a potent MAPK14 inhibitor through in silico target prediction and experimental validation, revealing its potential for repurposing in brain tumor treatment.

Transient Hsp90 suppression promotes a heritable change in protein translation

The paper shows that transient Hsp90 suppression causes a heritable change in protein translation that persists across generations.

Inhibition of mitochondrial ferredoxin 1 (FDX1) prevents adaptation to proteotoxic stress

This study identifies FDX1 inhibition as a strategy to prevent proteasome inhibitor resistance in cancer by targeting mitochondrial Fe-S cluster biosynthesis.

Oncogenic addiction to high 26S proteasome levels

This study shows cancer cells depend on high 26S proteasome levels for survival, and reducing 26S proteasome levels kills cancer cells while sparing normal cells.

NQO1 Binds And Supports SIRT1 Function

This study shows that SIRT1 regulates NQO1 expression and that NQO1 binds SIRT1 to mediate its protective role during mitochondrial stress.