Author

K. Harrington

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Evolutionary Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:differential expression· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:drug response / drug discovery· 2 Assay:scRNA-seq· 2 Organism:zebrafish· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

A. Melcher· 2 shared A. Claeys· 1 shared A. Rullan· 1 shared B. Boeckx· 1 shared B. Cole· 1 shared B. Decraene· 1 shared B. J. Y. Tan· 1 shared B. Kalfaoglu· 1 shared

Activity by Year

2017-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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2 shared papersCancer Biology

A. Melcher

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Cancer cell - fibroblast crosstalk via HB-EGF/EGFR/MEK signalling promotes macrophage recruitment in squamous cell carcinoma

G. Giangreco, A. Rullan, Y. Naito, D. Biwas, Y.-H. Liu, S. Hooper, P. Nenclares, S. Bhide, M. Cheang, P. Chakravarty, E. Hirata, C. Swanton, A. Melcher, K. Harrington, E. Sahai

The paper identifies a gene expression signature of cancer-fibroblast crosstalk in squamous cell carcinoma and shows its prognostic relevance and role in macrophage recruitment.

bioRxiv · Jul 13, 2023 · PreprintCancer Biology

Single-cell profiling and zebrafish avatars reveal LGALS1 as immunomodulating target in glioblastoma

L. Finotto, B. Cole, W. Giese, E. Baumann, A. Claeys, M. Vanmechelen, B. Decraene, M. Derweduwe, N. Dubroja Lakic, G. Shankar, M. Nagathihalli Kantharaju, J. P. Albrecht, I. Geudens, F. Stanchi, K. L. Ligon, , H. Gerhardt

The paper identifies LGALS1 as an immunomodulating target in glioblastoma by analyzing GAM-GBM interactions using single-cell RNA sequencing and zebrafish models.

bioRxiv · Apr 27, 2023 · PreprintCancer Biology

Single-cell level temporal profiling of tumour-reactive T cells under immune checkpoint blockade

J. Hassan, E. Appleton, B. Kalfaoglu, M. Pedersen, J. Almeida-Santos, H. Kanemaru, N. Irie, S. Foo, O. Reda, B. J. Y. Tan, I.-m. Okazaki, T. Okazaki, Y. Satou, K. Harrington, A. Melcher, M. Ono

This study uses a novel mouse model to analyze how checkpoint blockade affects tumour-reactive T cell activation dynamics at the single-cell level.

bioRxiv · Jul 19, 2022 · PreprintImmunology

Active Perception during Angiogenesis: Filopodia speed up Notch selection of tip cells in silico and in vivo

B. Zakirov, G. Charalambous, I. M. Aspalter, K. Van-Vuuren, T. Mead, K. Harrington, R. Thuret, E. Ravasz Regan, S. P. Herbert, K. Bentley

This study shows filopodia enhance Notch-mediated tip cell selection during angiogenesis through active perception mechanisms in both simulations and zebrafish embryos.

bioRxiv · Aug 22, 2020Cell Biology

Escalation of Memory Length in Finite Populations

K. Harrington, J. Pollack

This study shows that larger populations support greater escalation of strategic complexity in coevolutionary systems, resolving a long-standing counter-argument.

bioRxiv · Apr 25, 2017Evolutionary Biology