A. Melcher

Enhancing oncolytic virotherapy by exosome-mediated microRNA reprograming of the tumour microenvironment.

This study uses oncolytic viruses to deliver miRNA to TAMs, reversing their immunosuppressive activity and improving ovarian cancer immunotherapy efficacy.

IFNB induced by non-lytic virus immunotherapy promotes improved survival in hepatocellular carcinoma, mediated by MHCII-independent cytotoxic CD4+ T-cells

This paper shows that uv-inactivated reovirus combined with sorafenib improves survival in HCC by promoting IFNβ-induced cytotoxic CD4+ T-cell responses that are MHCII-independent.

PARP inhibitors enhance reovirus-mediated cell killing through the death-inducing signaling complex (DISC) with an associated NF-kappa B-regulated immune response.

This paper identifies PARP inhibitors as sensitizers for oncolytic reovirus by enhancing DISC-mediated apoptosis and NF-kappa B-driven immune responses.

Facilitating taxonomy and phylogenetics: An informative and cost-effective protocol integrating long amplicon PCRs and third-generation sequencing

This paper introduces a cost-effective PCR-based protocol for generating long amplicons of mitochondrial and nuclear genes in spiders, enabling accurate phylogenetic inference with low infrastructure requirements.

Cancer cell - fibroblast crosstalk via HB-EGF/EGFR/MEK signalling promotes macrophage recruitment in squamous cell carcinoma

The paper identifies a gene expression signature of cancer-fibroblast crosstalk in squamous cell carcinoma and shows its prognostic relevance and role in macrophage recruitment.

FUME-TCRseq: Sensitive and accurate sequencing of the T-cell receptor from limited input of degraded RNA

FUME-TCRseq is a sensitive and accurate method for TCR sequencing from low-quality RNA, outperforming existing methods in detecting clonotypes and enabling analysis of archival tissue samples.

DNA-PKcs is required for cGAS/STING-dependent viral DNA sensing in human cells

This study shows DNA-PK is essential for STING-dependent IFN-I responses to exogenous DNA and DNA virus infection in human cells.

CDK4/6 inhibition and dsRNA sensor agonism co-operate to enhance anti-cancer effects through ER stress and immune modulation of tumour cells

Single-cell level temporal profiling of tumour-reactive T cells under immune checkpoint blockade

This study uses a novel mouse model to analyze how checkpoint blockade affects tumour-reactive T cell activation dynamics at the single-cell level.

Environmental DNA from archived leaves reveals widespread temporal turnover and biotic homogenization in forest arthropod communities

The paper uses environmental DNA from archived leaves to show temporal turnover and biotic homogenization in forest arthropod communities, not widespread declines in diversity.