Activation of GSDME compensates for GSDMD deficiency in a mouse model of NLRP3 inflammasomopathy
C. Wang, T. Yang, J. Xiao, C. Xu, Y. Alippe, K. Sun, T.-D. Kanneganti, J. B. Monahan, Y. Abu-Amer, J. Lieberman, G. Mbalaviele
This study shows that GSDME compensates for GSDMD deficiency in NLRP3 inflammasomopathy, revealing a GSDME-dependent inflammatory pathway and suggesting dual inhibition of GSDMD and GSDME for therapeutic benefit.
bioRxiv · Jan 6, 2021 · PreprintImmunology