Author

Y. Abu-Amer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Immunology· 2 Biochemistry· 1 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 4 Organism:mouse· 4 Research Focus:cell signaling & trafficking· 3 Research Focus:development & morphogenesis· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

G. Mbalaviele· 4 shared C. Wang· 3 shared C. Xu· 2 shared J. Xiao· 2 shared K. Sun· 2 shared T. Yang· 2 shared Y. Alippe· 2 shared D. Hao· 1 shared

Activity by Year

2021-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

4 shared papersImmunology

G. Mbalaviele

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Chemotherapy activates inflammasomes to cause inflammation-associated bone loss

C. Wang, K. Kaur, C. Xu, Y. Abu-Amer, G. Mbalaviele

This study shows doxorubicin causes bone loss via inflammasome activation, leading to pyroptosis and NETosis, and identifies AIM2 and NLRP3 as key mediators.

bioRxiv · Oct 6, 2023Cell Biology

Tenotomy-induced muscle atrophy is sex-specific and independent of NFκB

G. A. Meyer, S. Thomopoulos, Y. Abu-Amer, K. Shen

This study shows that tenotomy-induced muscle atrophy is sex-specific and not dependent on NFκB, but may involve autophagy differences between males and females.

bioRxiv · Jul 26, 2022Physiology

Glutamine metabolism modulates chondrocyte inflammatory response

M. Arra, G. Swarnkar, N. S. Adapala, S.-K. B. Naqvi, L. Cai, M. Farooq Rai, G. Mbalaviele, R. Brophy, Y. Abu-Amer

This study shows that glutamine metabolism in chondrocytes influences inflammatory responses and autophagy, with glutamine deprivation reducing inflammation by inhibiting NF-κB.

bioRxiv · Jun 9, 2022Biochemistry

Fracture healing is delayed in the absence of gasdermin signaling

G. Mbalaviele, K. Sun, C. Wang, J. Xiao, M. D. Brodt, L. Yuan, T. Yang, Y. Alippe, H. Hu, D. Hao, Y. Abu-Amer, M. Silva, J. Shen

This study shows that gasdermin signaling is essential for fracture healing, as its absence delays bone callus formation and reduces biomechanical properties.

bioRxiv · Nov 29, 2021Immunology

Activation of GSDME compensates for GSDMD deficiency in a mouse model of NLRP3 inflammasomopathy

C. Wang, T. Yang, J. Xiao, C. Xu, Y. Alippe, K. Sun, T.-D. Kanneganti, J. B. Monahan, Y. Abu-Amer, J. Lieberman, G. Mbalaviele

This study shows that GSDME compensates for GSDMD deficiency in NLRP3 inflammasomopathy, revealing a GSDME-dependent inflammatory pathway and suggesting dual inhibition of GSDMD and GSDME for therapeutic benefit.

bioRxiv · Jan 6, 2021 · PreprintImmunology