Author

J. Baell

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:cancer & tumor microenvironment· 1 Organism:human· 1 Organism:mouse· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

A. B. Tobin· 1 shared A. Christopoulos· 1 shared A. E. Berizzi· 1 shared C. J. Langmead· 1 shared C. Valant· 1 shared C. W. Lindsley· 1 shared D. M. Thal· 1 shared E. T. van der Westhuizen· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperPharmacology & Toxicology

A. B. Tobin

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2 papers

Recent·Most cited

A small molecule inhibitor of PTP1B and PTPN2 enhances T cell anti-tumor immunity

S. Liang, E. Tran, X. Du, J. Dong, H. Sudholz, H. Chen, Z. Qu, N. Huntington, J. Babon, N. Kershaw, Z.-Y. Zhang, J. Baell, F. Wiede, T. Tiganis

This study shows that a PTP1B/PTPN2 inhibitor enhances T cell anti-tumor immunity in mice, improves tumor response to PD1 therapy, and avoids immune-related toxicities.

bioRxiv · Jun 16, 2023 · PreprintCancer Biology

Crystal structure of the M5 muscarinic acetylcholine receptor

Z. Vuckovic, P. R. Gentry, A. E. Berizzi, K. Hirata, S. Varghese, G. Thompson, E. T. van der Westhuizen, W. A. C. Burger, R. Rahmani, C. Valant, C. J. Langmead, C. W. Lindsley, J. Baell, A. B. Tobin, P. M. Sexton, , D. M. Thal

The paper reports the crystal structure of the human M5 muscarinic acetylcholine receptor bound to tiotropium, revealing structural differences that inform ligand selectivity design.

bioRxiv · Aug 14, 2019Pharmacology & Toxicology