M. M. Hill

Imetelstat-Mediated Alterations in Fatty Acid Metabolism To Induce Ferroptosis As Therapeutic Strategy for Acute Myeloid Leukemia

This study identifies ferroptosis as a mechanism by which imetelstat induces therapeutic effects in AML, showing that targeting fatty acid metabolism enhances its efficacy.

Systemic host inflammation induces stage-specific transcriptomic modification and slower maturation in malaria parasites

The paper shows that systemic host inflammation slows malaria parasite maturation and alters their transcriptomic profile in vivo.

Expression of CD49f defines subsets of human regulatory T cells with divergent transcriptional landscape and function that correlate with ulcerative colitis disease activity

The paper identifies CD49f-expressing subsets of human regulatory T cells with distinct transcriptional profiles and functions linked to ulcerative colitis disease activity.

In vivo proteomic mapping through GFP-directed proximity dependent biotin labelling in zebrafish

The paper introduces a method to map protein interactions in zebrafish using GFP-directed biotin labelling and applies it to study caveolin interactors in muscle cells.

An inverted Caveolin-1 topology defines a novel exosome secreted from prostate cancer cells

The paper identifies an inverted Cav1 topology in exosomes secreted by prostate cancer cells, revealing a non-canonical autophagy pathway involved in disease progression.

Marizomib suppresses triple-negative breast cancer via proteasome and oxidative phosphorylation inhibition

Marizomib inhibits primary tumor growth and reduces lung and brain metastases in pre-clinical triple-negative breast cancer models.

Serum glycoprotein biomarker validation for esophageal adenocarcinoma and application to Barrett’s surveillance

The paper validates serum glycoprotein biomarkers for esophageal adenocarcinoma and develops a panel for Barrett’s surveillance.