Meningeal Regulatory T cell-derived enkephalin gates nociception
E. Midavaine, B. C. Moraes, J. Benitez, S. R. Rodriguez, J. M. Braz, N. P. Kochhar, W. L. Eckalbar, A. I. Domingos, J. E. Pintar, A. I. Basbaum, S. W. Kashem
This study identifies meningeal regulatory T cells (mTregs) expressing enkephalin that modulate mechanical pain sensitivity in female mice via a sex hormone-dependent opioid receptor mechanism.
bioRxiv · May 11, 2024 · PreprintImmunology