Author

S. J. Elledge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 1 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1 Approach:statistical model· 1

Frequent Co-Authors

A. Dumaine· 1 shared A. L. Hillis· 1 shared A. Toker· 1 shared C. M. Bergey· 1 shared D. A. Fruman· 1 shared D. E. Root· 1 shared E. Lecky· 1 shared E. Schurr· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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1 shared paperEvolutionary Biology

A. Dumaine

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Author profile →

2 papers

Recent·Most cited

Cholesterol biosynthesis inhibition synergizes with AKT inhibitors in triple-negative breast cancer

A. Toker, A. L. Hillis, T. D. Martin, H. E. Manchester, J. M. Hogstrom, N. Zhang, E. Lecky, N. Kozlova, N. S. Persky, D. E. Root, M. Brown, K. Cichowski, S. J. Elledge, T. Muranen, D. A. Fruman, , R. R. Madsen

This study identifies a synergistic effect between AKT inhibitors and pitavastatin in killing triple-negative breast cancer cells by targeting cholesterol trafficking.

bioRxiv · Jan 16, 2024 · PreprintCancer Biology

Natural selection contributed to immunological differences between human hunter-gatherers and agriculturalists

G. F. Harrison, J. Sanz, J. Boulais, M. J. Mina, J.-C. Grenier, Y. Leng, A. Dumaine, V. Yotova, C. M. Bergey, S. J. Elledge, E. Schurr, L. Quintana-Murci, G. H. Perry, L. B. Barreiro

The paper compares transcriptional immune responses between hunter-gatherers and agriculturalists, finding greater divergence in viral response and evidence of natural selection in hunter-gatherers.

bioRxiv · Dec 4, 2018Evolutionary Biology