Author

V. Gopalan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 1 Biophysics· 1 Pathology· 1 Plant Biology· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 5 Research Focus:cell type annotation· 5 Approach:statistical model· 5 Research Focus:differential expression· 3 Approach:experimental assay· 3 Research Focus:drug response / drug discovery· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2

Frequent Co-Authors

C.-P. Day· 3 shared S. Hannenhalli· 3 shared A. Sassano· 2 shared C. Smith· 2 shared E. Perez-Guijarro· 2 shared E. Wu· 2 shared G. Merlino· 2 shared J. Ebersole· 2 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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3 shared papersCancer Biology

C.-P. Day

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Author profile →

7 papers

Recent·Most cited

Stress Granule Protein TZF1 Enhances Salt Stress Tolerance by Targeting ACA11 mRNA for Degradation in Arabidopsis

S.-L. He, B. Li, W. J. Zahurancik, H. C. Arthur, V. Sidharthan, V. Gopalan, L. Wang, J.-C. Jang

This study identifies TZF1 as a stress granule protein that enhances salt stress tolerance in Arabidopsis by degrading ACA11 mRNA, thereby upregulating salt tolerance genes.

bioRxiv · Jan 12, 2024 · PreprintPlant Biology

Mapping the MOB proteins' proximity network reveals a unique interaction between human MOB3C and the RNase P complex

I. E. Elkholi, J. Boulais, M.-P. Thibault, H.-D. Phan, A. Robert, L. B. Lai, D. Faubert, M. J. Smith, V. Gopalan, J.-F. Cote

bioRxiv · May 11, 2023Biochemistry

Melanoma clonal subline analysis uncovers heterogeneity-driven immunotherapy resistance mechanisms

C. Gruen, H. H. Yang, A. Sassano, E. Wu, V. Gopalan, K. L. Marie, A. Castro, F. R. Mehrabadi, C. H. Wu, I. Church, G. A. Needle, C. Smith, S. Chin, J. Ebersole, C. Marcelus, , E. Perez-Guijarro

The paper analyzes melanoma clonal sublines to uncover how intratumoral heterogeneity drives resistance to immunotherapy.

bioRxiv · Apr 3, 2023 · PreprintCancer Biology

RNAs undergo phase transitions with lower critical solution temperatures

G. M. Wadsworth, W. J. Zahurancik, X. Zeng, P. Pullara, L. B. Lai, V. Sidharthan, R. V. Pappu, V. Gopalan, P. R. Banerjee

The paper shows RNAs undergo phase transitions with lower critical solution temperatures, driven by Mg2+ and phosphate backbone interactions, and can suppress RNase P activity.

bioRxiv · Oct 17, 2022Biophysics

Transitory Schwann Cell Precursor and hybrid states underpin melanoma therapy resistance and metastasis

V. Gopalan, C. W. Wong, R. Leshem, L. Owen, T. Vallius, Y. Shi, Y. Jiang, E. Perez-Guijarro, E. Wu, S. Chin, J. Ebersole, C. Smith, A. Sassano, M. Alves Constantino, M. J. Haley, , K. L. Marie

This paper identifies transitory Schwann Cell Precursor and hybrid states in melanoma that correlate with therapy resistance and metastasis, and shows targeting Hdac2 can sensitize tumors to treatment.

bioRxiv · Oct 14, 2022 · PreprintCancer Biology

Broad misappropriation of developmental splicing profile by cancer in multiple organs

A. Singh, A. Rajeevan, V. Gopalan, P. Agrawal, C.-P. Day, S. Hannenhalli

The paper shows cancer reactivates embryonic splicing events, linking development and cancer through splicing factors and identifies potential therapeutic targets.

bioRxiv · Dec 13, 2021Cancer Biology

Rapamycin as a potent and selective inhibitor of vascular endothelial growth factor receptor in breast carcinoma

W. F. Wan Abdul rahman, M. S. Muhammad Sakri, T. A. D. A.-A. Tengku Din, H. Jaafar, V. Gopalan

This study evaluates rapamycin and platelet factor-4 on rat breast carcinoma, finding rapamycin effectively downregulates Flt-4 while platelet factor-4 shows limited anti-angiogenic effects.

bioRxiv · Aug 27, 2020Pathology