Author

J. C. Taylor

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biophysics· 1 Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:deep learning· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Ashworth· 1 shared A. E. Handel· 1 shared A. R. Renslo· 1 shared A. S. Gkazi· 1 shared A. T. Pagnamenta· 1 shared A. White· 1 shared B. C. Lagerholm· 1 shared B. K. Shoichet· 1 shared

Activity by Year

2021-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperBiophysics

A. Ashworth

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Iterative computational design and crystallographic screening identifies potent inhibitors targeting the Nsp3 Macrodomain of SARS-CoV-2

S. Gahbauer, G. J. Correy, M. Schuller, M. P. Ferla, Y. U. Doruk, M. Rachman, T. Wu, M. Diolaiti, S. Wang, J. Neitz, D. Fearon, D. S. Radchenko, Y. Moroz, J. J. Irwin, A. R. Renslo, , J. S. Fraser

The paper computationally designs and experimentally validates potent inhibitors of the SARS-CoV-2 Nsp3 Macrodomain, identifying 160 ligands and 152 crystal structures with submicromolar affinity.

bioRxiv · Jun 27, 2022Biophysics

A pathogenicity locus of Streptococcus gallolyticus subspecies gallolyticus

J. C. Taylor, R. Kumar, J. Xu, Y. Xu

This study identifies a chromosomal locus in Streptococcus gallolyticus subspecies gallolyticus that is critical for its pathogenicity in colorectal cancer.

bioRxiv · Mar 15, 2022 · PreprintMicrobiology

A FOXN1 mutation competitively displaces wild-type FOXN1 from higher order nuclear condensates to cause immunodeficiency

I. A. Rota, A. E. Handel, F. Klein, S. Maio, F. Dhalla, M. E. Deadman, S. Cheuk, J. A. Newman, Y. S. Michaels, S. Zuklys, N. Prevot, P. Hublitz, P. D. Charles, A. S. Gkazi, E. Adamopoulou, , G. A. Hollander

This paper identifies a FOXN1 mutation that displaces wild-type FOXN1 from nuclear condensates, leading to immunodeficiency and athymia in heterozygotes.

bioRxiv · Mar 28, 2021 · PreprintImmunology