Author

J. C. Williamson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Immunology· 2

Signature Assays, Organisms & Methods

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Organism:human· 6 Assay:proteomics· 5 Approach:experimental assay· 4 Research Focus:host-pathogen & immune response· 4 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1

Frequent Co-Authors

P. J. Lehner· 6 shared E. J. Greenwood· 4 shared N. J. Matheson· 4 shared A. Naamati· 3 shared S. Marelli· 2 shared A. Bateman· 1 shared A. J. Rutkowski· 1 shared A. O. Speak· 1 shared

Activity by Year

2018-2021 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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6 shared papersMicrobiology

P. J. Lehner

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

EROS is a selective chaperone regulating the phagocyte NADPH oxidase and purinergic signalling

L. O. Randzavola, P. M. Mortimer, E. C. Garside, E. R. Dufficy, A. Schejtman, G. Roumelioti, L. Yu, M. Pardo, K. Spirohn, C. Tolley, C. Brandt, K. Harcourt, E. Nichols, M. Nahorski, G. Woods, , D. C. Thomas

This study identifies EROS as a chaperone essential for gp91phox maturation and P2X7 receptor function, revealing its role in immune responses and infection resistance.

bioRxiv · Sep 14, 2021Immunology

ADNKA overcomes SARS-CoV2-mediated NK cell inhibition through non-spike antibodies

C. A. Fielding, P. Sabberwal, J. C. Williamson, E. J. Greenwood, E. Crozier, W. Zelek, J. Seow, C. Graham, I. Huettner, J. Edgeworth, B. P. Morgan, K. Ladell, M. Eberl, I. R. Humphreys, B. Merrick, , R. J. Stanton

This study identifies ADNKA as a mechanism by which SARS-CoV-2-infected cells evade NK cell inhibition, showing that non-spike antibodies drive sustained NK activation and cytokine production.

bioRxiv · Apr 6, 2021Immunology

Dissecting HSV-1-induced host shut-off at RNA level

C. C. Friedel, A. W. Whisnant, L. Djakovic, A. J. Rutkowski, M.-S. Friedl, M. Kluge, J. C. Williamson, S. Sai, R. O. Vidal, S. Sauer, T. Hennig, B. Prusty, P. J. Lehner, N. J. Matheson, F. Erhard, L. Dölken

This study quantifies HSV-1-induced host shut-off mechanisms and identifies gene-specific transcriptional changes during early infection.

bioRxiv · May 20, 2020 · PreprintMicrobiology

Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest

S. Marelli, J. C. Williamson, A. V. Protasio, A. Naamati, E. J. Greenwood, J. E. Deane, P. J. Lehner, N. J. Matheson

This study identifies HIV-1 Vif amino acid polymorphisms that regulate PP2A antagonism and demonstrate that this function causes G2/M cell cycle arrest independently of APOBEC3 proteins.

bioRxiv · Oct 31, 2019Microbiology

Promiscuous targeting of cellular proteins by Vpr drives massive proteomic remodelling in HIV-1 infection

E. J. Greenwood, J. C. Williamson, A. Sienkiewicz, A. Naamati, N. J. Matheson, P. J. Lehner

The paper identifies Vpr as the main driver of proteomic changes in HIV-1 infection by degrading multiple host proteins.

bioRxiv · Jan 8, 2019Microbiology

Functional proteomic atlas of HIV-infection inprimary human CD4+ T cells

A. Naamati, J. C. Williamson, E. J. Greenwood, S. Marelli, P. J. Lehner, N. J. Matheson

This study provides a functional proteomic atlas of HIV infection in primary human CD4+ T cells, revealing 650 significantly perturbed proteins, many regulated by viral accessory proteins.

bioRxiv · Aug 10, 2018Microbiology