Author

N. J. Matheson

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 8 Cancer Biology· 2 Immunology· 2 Biochemistry· 1

Signature Assays, Organisms & Methods

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Organism:human· 11 Approach:experimental assay· 10 Research Focus:host-pathogen & immune response· 5 Assay:proteomics· 5 Research Focus:cell type annotation· 4 Approach:statistical model· 4 Assay:bulk RNA-seq· 3 Research Focus:cell signaling & trafficking· 2

Frequent Co-Authors

A. Naamati· 5 shared P. J. Lehner· 5 shared E. J. Greenwood· 4 shared J. C. Williamson· 4 shared S. Marelli· 3 shared A. Ali· 2 shared A. J. Rutkowski· 2 shared A. V. Protasio· 2 shared

Activity by Year

2018-2023 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 25 mutual co-author links

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5 shared papersMicrobiology

A. Naamati

Mutual co-authors in cluster

Author profile →

13 papers

Recent·Most cited

Gut microbiome remains stable following COVID-19 vaccination in healthy and immuno-compromised individuals

R. H. Boston, R. Guan, L. Kalmar, S. Beier, E. C. Horner, N. Beristain-Covarrubias, J. C. Yam-Puc, P. P. Gerber, L. Faria, A. Kuroshchenkova, A. E. Lindell, S. Blasche, A. Correa-Noguera, A. Elmer, C. Saunders, , K. R. Patil

This study shows that the gut microbiome remains stable after COVID-19 vaccination in both healthy and immuno-compromised individuals, with no significant changes in diversity, phylum, species, or functional capacity.

bioRxiv · Aug 23, 2023Microbiology

Screening in serum-derived medium reveals differential response to compounds targeting metabolism

K. L. Abbott, A. Ali, D. Casalena, B. T. Do, R. Ferreira, J. H. Cheah, C. K. Soule, A. Deik, T. Kunchok, D. R. Schmidt, S. Renner, S. E. Honeder, M. Wu, S. H. Chan, T. Tseyang, , M. G. Vander Heiden

The paper screens compounds targeting metabolism in serum-derived medium to identify differential responses in cancer cells, aiming to improve drug response prediction.

bioRxiv · Feb 25, 2023Cancer Biology

Microfluidics-enabled fluorescence-activated cell sorting of single pathogen-specific antibody secreting cells for the rapid discovery of monoclonal antibodies

K. Fischer, A. Lulla, T. So, P. Pereyra-Gerber, M. I. J. Raybould, T. N. Kohler, T. S. Kaminski, J. C. Yam-Puc, R. Hughes, F. Leiss-Maier, P. Brear, N. J. Matheson, C. Deane, M. Hyvonen, J. Thaventhiran, F. Hollfelder

This paper presents a microfluidics-based method to rapidly discover monoclonal antibodies from antigen-specific antibody secreting cells, achieving high-affinity and neutralizing antibodies against SARS-CoV-2.

bioRxiv · Jan 10, 2023Immunology

Attenuated humoral responses in HIV infection after SARS-CoV-2 vaccination are linked to global B cell defects and cellular immune profiles

E. Touizer, A. Alrubbayi, R. Ford, N. Hussain, P. Pereyra Gerber, H.-L. Shum, C. Rees-Spear, L. Muir, E. Gea-Mallorqui, J. Kopycinski, D. Jankovic, C. Pinder, T. A. Fox, I. Williams, C. Mullender, , L. E. McCoy

This study examines humoral and cellular immune responses to SARS-CoV-2 vaccination in HIV-infected individuals, finding reduced antibody responses and B cell dysfunction, but robust T cell responses.

bioRxiv · Nov 11, 2022 · PreprintImmunology

A protease-activatable luminescent biosensor andreporter cell line for authentic SARS-CoV-2 infection

P. Pereyra Gerber, L. M. Duncan, E. J. Greenwood, S. Marelli, A. Naamati, A. Teixeira-Silva, T. W. Crozier, I. Gabaev, J. R. Zhan, T. E. Mulroney, E. C. Horner, R. Doffinger, A. E. Willis, J. E. Thanventhiran, A. V. Protasio, N. J. Matheson

This paper develops a luminescent biosensor and reporter cell line to quantify SARS-CoV-2 infection and neutralising antibodies efficiently.

bioRxiv · Mar 22, 2021Microbiology

Increased demand for NAD+ relative to ATP drives aerobic glycolysis

A. Luengo, Z. Li, D. Y. Gui, L. B. Sullivan, M. Zagorulya, B. T. Do, R. Ferriera, A. Naamati, A. Ali, C. A. Lewis, C. J. Thomas, S. Spranger, N. J. Matheson, M. G. Vander Heiden

The paper shows that increased NAD+ demand relative to ATP demand drives aerobic glycolysis by impairing NAD+ regeneration and promoting fermentation.

bioRxiv · Jun 8, 2020Biochemistry

Dissecting HSV-1-induced host shut-off at RNA level

C. C. Friedel, A. W. Whisnant, L. Djakovic, A. J. Rutkowski, M.-S. Friedl, M. Kluge, J. C. Williamson, S. Sai, R. O. Vidal, S. Sauer, T. Hennig, B. Prusty, P. J. Lehner, N. J. Matheson, F. Erhard, L. Dölken

This study quantifies HSV-1-induced host shut-off mechanisms and identifies gene-specific transcriptional changes during early infection.

bioRxiv · May 20, 2020 · PreprintMicrobiology

Dissecting cell type-specific metabolism in pancreatic ductal adenocarcinoma

A. N. Lau, Z. Li, L. V. Danai, A. M. Westermark, A. M. Darnell, R. Ferreira, V. Gocheva, S. Sivanand, E. C. Lien, K. M. Sapp, J. R. Mayers, G. Biffi, C. R. Chin, S. M. Davidson, D. A. Tuveson, , M. Vander Heiden

The paper uses isotope tracing to compare metabolism between cancer cells and fibroblasts in pancreatic tumors, identifying key metabolic dependencies in cancer cells.

bioRxiv · Mar 9, 2020Cancer Biology

Antagonism of PP2A is an independent and conserved function of HIV-1 Vif and causes cell cycle arrest

S. Marelli, J. C. Williamson, A. V. Protasio, A. Naamati, E. J. Greenwood, J. E. Deane, P. J. Lehner, N. J. Matheson

This study identifies HIV-1 Vif amino acid polymorphisms that regulate PP2A antagonism and demonstrate that this function causes G2/M cell cycle arrest independently of APOBEC3 proteins.

bioRxiv · Oct 31, 2019Microbiology

EWI-2 Inhibits Cell-Cell Fusion at the HIV-1 Virological Presynapse

E. E. Whitaker, N. J. Matheson, S. Perlee, P. B. Munson, M. Symeonides, M. Thali

The paper identifies EWI-2 as a host factor that inhibits HIV-1 Env-mediated cell-cell fusion at the virological presynapse, contributing to the prevention of syncytia formation.

bioRxiv · Oct 15, 2019Microbiology

Integrative functional genomics decodes herpes simplex virus 1

A. W. Whisnant, C. S. Juerges, T. Hennig, E. Wyler, B. Prusty, A. J. Rutkowski, A. L'Hernault, M. Goebel, K. Doering, J. Menegatti, R. Antrobus, N. J. Matheson, F. W. Kuenzig, G. Mastrobuoni, C. Bielow, , L. Doelken

This study decodes the complete HSV-1 transcriptome and translatome during lytic infection, identifying novel transcripts, ORFs, and regulatory elements.

bioRxiv · Apr 9, 2019Microbiology

Promiscuous targeting of cellular proteins by Vpr drives massive proteomic remodelling in HIV-1 infection

E. J. Greenwood, J. C. Williamson, A. Sienkiewicz, A. Naamati, N. J. Matheson, P. J. Lehner

The paper identifies Vpr as the main driver of proteomic changes in HIV-1 infection by degrading multiple host proteins.

bioRxiv · Jan 8, 2019Microbiology

Functional proteomic atlas of HIV-infection inprimary human CD4+ T cells

A. Naamati, J. C. Williamson, E. J. Greenwood, S. Marelli, P. J. Lehner, N. J. Matheson

This study provides a functional proteomic atlas of HIV infection in primary human CD4+ T cells, revealing 650 significantly perturbed proteins, many regulated by viral accessory proteins.

bioRxiv · Aug 10, 2018Microbiology