Author

L. Dölken

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:host-pathogen & immune response· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Approach:deep learning· 1

Frequent Co-Authors

F. Erhard· 4 shared T. Hennig· 3 shared A. W. Whisnant· 2 shared B. Prusty· 2 shared M. Trilling· 2 shared V. T. K. Le-Trilling· 2 shared A. Grothey· 1 shared A. Halenius· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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4 shared papersMicrobiology

F. Erhard

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Multimodal HLA-I genotype regulation by human cytomegalovirus US10 and resulting surface patterning

C. Gerke, L. Bauersfeld, V. Oberhardt, C. Jürges, R. Spaapen, C. Mussolino, V. T. K. Le-Trilling, M. Trilling, L. Dölken, F. Erhard, M. Hofmann, H. Hengel, F. Momburg, A. Halenius

This study investigates how HCMV US10 protein regulates HLA-I genotype and surface expression, revealing its multimodal effects on different HLA-I allotypes.

bioRxiv · Jan 10, 2023Microbiology

Multi-omics reveals principles of gene regulation and pervasive non-productive transcription in the human cytomegalovirus genome

C. S. Jürges, M. Lodha, V. T. K. Le-Trilling, P. Bhandare, E. Wolf, A. Zimmermann, M. Trilling, B. Prusty, L. Dölken, F. Erhard

The paper uses multi-omics data to model HCMV gene regulation, identifying over 2,600 viral transcripts and explaining protein expression kinetics through transcription start sites and RNA stability.

bioRxiv · Jan 7, 2022 · PreprintMicrobiology

pUL36 de-ubiquitinase activity augments both the initiation and progression of lytic virus infection in IFN-primed cells

J. Mohnke, I. Stark, M. Fischer, A. Grothey, P. O'Hare, B. Sodeik, F. Erhard, L. Dölken, T. Hennig

This study shows that pUL36 DUB activity helps HSV-1 overcome IFN resistance and enhance lytic infection in IFN-primed cells.

bioRxiv · Jan 29, 2021 · PreprintMicrobiology

Concatemeric Broccoli reduces mRNA stability, aggregates and induces p-body formation

M. R. Rink, M. A. P. Baptista, T. Hennig, A. W. Whisnant, N. Wolf, J. Seibel, L. Dölken, J. B. Bosse

This study investigates the effects of Broccoli-aptamer concatemers on mRNA stability, aggregation, and p-body formation in different cellular contexts.

bioRxiv · Dec 7, 2020 · PreprintMicrobiology

Dissecting HSV-1-induced host shut-off at RNA level

C. C. Friedel, A. W. Whisnant, L. Djakovic, A. J. Rutkowski, M.-S. Friedl, M. Kluge, J. C. Williamson, S. Sai, R. O. Vidal, S. Sauer, T. Hennig, B. Prusty, P. J. Lehner, N. J. Matheson, F. Erhard, L. Dölken

This study quantifies HSV-1-induced host shut-off mechanisms and identifies gene-specific transcriptional changes during early infection.

bioRxiv · May 20, 2020 · PreprintMicrobiology