Author

J. Cubuk

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biophysics· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Organism:virus· 2 Approach:biophysical modeling· 1 Research Focus:cell signaling & trafficking· 1 Organism:human· 1

Frequent Co-Authors

A. S. Holehouse· 3 shared M. D. Stuchell-Brereton· 3 shared A. Soranno· 2 shared J. J. Alston· 2 shared J. J. Incicco· 2 shared K. B. Hall· 2 shared A. E. Greenberg· 1 shared A. J. Soranno· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersBiophysics

A. S. Holehouse

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Structural dynamics of the intrinsically disordered linker region of cardiac troponin T

J. Cubuk, L. Greenberg, A. E. Greenberg, R. J. Emenecker, M. D. Stuchell-Brereton, A. S. Holehouse, A. J. Soranno, M. J. Greenberg

This paper investigates the structural dynamics of the intrinsically disordered troponin-T linker region using single-molecule FRET, molecular dynamics simulations, and functional assays, showing its dynamic behavior and how a mutation affects intermolecular interactions.

bioRxiv · May 30, 2024 · PreprintBiophysics

The disordered N-terminal tail of SARS CoV-2 Nucleocapsid protein forms a dynamic complex with RNA

J. Cubuk, J. J. Alston, J. J. Incicco, A. S. Holehouse, K. B. Hall, M. D. Stuchell-Brereton, A. Soranno

This study investigates how the disordered N-terminal tail of the SARS-CoV-2 Nucleocapsid protein enhances RNA binding affinity and modulates interactions with RNA.

bioRxiv · Feb 10, 2023Biophysics

The SARS-CoV-2 nucleocapsid protein is dynamic, disordered, and phase separates with RNA

J. Cubuk, J. J. Alston, J. J. Incicco, S. Singh, M. D. Stuchell-Brereton, M. D. Ward, M. I. Zimmerman, N. Vithani, D. Griffith, J. A. Wagoner, G. R. Bowman, K. B. Hall, A. Soranno, A. S. Holehouse

This study investigates the SARS-CoV-2 nucleocapsid protein's dynamics, disorder, and RNA phase separation using single-molecule spectroscopy and simulations, revealing its multivalent RNA binding properties and phase separation behavior.

bioRxiv · Jun 17, 2020Biophysics