Author

J. Chiaravalli

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 4 Biochemistry· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:drug response / drug discovery· 4 Research Focus:host-pathogen & immune response· 3 Organism:human· 3 Assay:proteomics· 3 Organism:virus· 2 Approach:deep learning· 1 Assay:structural biology· 1

Frequent Co-Authors

F. Agou· 5 shared E. Giraud· 3 shared B. Meyer· 2 shared E. Simon-Loriere· 2 shared J. Tran-Rajau· 2 shared S. Van Der Werf· 2 shared A. Blondel· 1 shared A. Grauslys· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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Curved chords = mutual co-authorship

5 shared papersMicrobiology

F. Agou

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

High throughput screening identifies broad-spectrum Coronavirus entry inhibitors

S. Khan, E. O. Partuk, J. Chiaravalli, N. Kozer, K. A. Shurrush, Y. Elbaz-Alon, N. Scher, E. Giraud, J. Tran-Rajau, F. Agou, H. M. Barr, O. Avinoam

This study uses high-throughput screening to identify small molecule inhibitors that block coronavirus entry, finding a novel broad-spectrum antiviral.

bioRxiv · Dec 4, 2023Microbiology

Enhanced neutralization escape to therapeutic monoclonal antibodies by SARS-CoV-2 Omicron sub-lineages

F. Touret, E. Giraud, J. Bourret, F. Donati, J. Tran-Rajau, J. Chiaravalli, F. Lemoine, F. Agou, E. Simon-Loriere, S. Van Der Werf, X. de Lamballerie

This study evaluates the neutralizing activity of monoclonal antibodies against SARS-CoV-2 Omicron sub-lineages and finds reduced efficacy against several variants.

bioRxiv · Dec 22, 2022Microbiology

Potent Human Broadly SARS-CoV-2 Neutralizing IgA and IgG Antibodies Effective Against Omicron BA.1 and BA.2

C. Planchais, I. Fernandez, T. Bruel, G. Dias de Melo, M. Prot, M. Beretta, P. Guardado-Calvo, J. Dufloo, L. M. Molinos-Albert, M. Backovic, J. Chiaravalli, E. Giraud, B. Vesin, L. Conquet, L. Grzelak, , H. Mouquet

The paper identifies potent broadly neutralizing IgA and IgG antibodies against SARS-CoV-2 variants, including Omicron BA.1 and BA.2, from memory B cells in convalescents.

bioRxiv · Apr 1, 2022Immunology

A highly sensitive cell-based luciferase assay for high-throughput automated screening of SARS-CoV-2 nsp5/3CLpro inhibitors

K.-Y. Chen, T. Krischuns, L. Ortega Varga, E. Harigua-Souiai, S. Paisant, A. Zettor, J. Chiaravalli, D. Courtney, A. O'Brien, S. Baker, C. Isel, F. Agou, Y. Jacob, A. Blondel, N. Naffakh

The paper develops a sensitive cell-based luciferase assay for high-throughput screening of SARS-CoV-2 nsp5/3CLpro inhibitors and identifies four effective compounds.

bioRxiv · Dec 18, 2021Microbiology

SARS-CoV-2 RBD in vitro evolution follows contagious mutation spread, yet generates an able infection inhibitor

J. Zahradnik, S. Marciano, M. Shemesh, E. Zoler, J. Chiaravalli, B. Meyer, Y. Rudich, O. Dym, N. Elad, G. Schreiber

The paper shows that in vitro evolved SARS-CoV-2 RBD mutations, like S477N, E484K, and N501Y, correlate with increased infectivity and are inhibited by high-affinity RBD drugs.

bioRxiv · Jan 6, 2021Biochemistry

Characterisation of protease activity during SARS-CoV-2 infection identifies novel viral cleavage sites and cellular targets with therapeutic potential

B. Meyer, J. Chiaravalli, S. Gellenoncourt, P. Brownridge, D. P. Bryne, L. A. Daly, A. Grauslys, M. Walter, F. Agou, L. A. Chakrabarti, C. S. Craik, C. E. Eyers, P. A. Eyers, Y. Gambin, A. R. Jones, , E. Emmott

This study identifies novel SARS-CoV-2 protease cleavage sites and cellular targets using mass spectrometry, showing that targeting these proteins can inhibit viral replication.

bioRxiv · Sep 16, 2020Microbiology