N. Jouvenet

Hepatitis E Virus-induced antiviral response by plasmacytoid dendritic cells is modulated by the ORF2 protein

This study shows that Hepatitis E Virus (HEV) ORF2 protein modulates plasmacytoid dendritic cell (pDC)-mediated antiviral responses by affecting pDC recognition of infected cells.

Tick-borne flavivirus NS5 antagonizes interferon signaling by inhibiting the catalytic activity of TYK2

This study identifies a mechanism by which tick-borne flaviviruses inhibit interferon signaling by targeting TYK2 catalytic activity through their NS5 protein.

Temperature sensitivity of bat antibodies links metabolic state with antigen-recognition diversity

This study shows that bat antibodies change their antigen-binding properties with temperature, linking metabolic state to immune diversity and anti-inflammatory function.

Integrated protein-protein interaction and RNA interference screens reveal novel restriction and dependency factors for a tick-borne flavivirus in its human host

The paper identifies novel host proteins interacting with TBEV and characterizes their role as dependency or restriction factors using PPI screens and RNAi.

Transcriptomic analysis of sorted lung cells revealed a proviral activity of the NF- κB pathway towards SARS-CoV-2

The paper analyzes transcriptomic data from sorted SARS-CoV-2 infected lung cells to show the NF-κB pathway promotes viral replication while CYLD inhibits it.

Discovery of genes that modulate flavivirus replication in an interferon-dependent manner

The paper identifies twenty-one host genes that modulate flavivirus replication in an interferon-dependent manner using siRNA screening in ZIKV-infected microglial cells.

Species-specific molecular barriers to SARS-CoV-2 replication in bat cells

The paper investigates SARS-CoV-2 replication in bat cells and finds species-specific molecular barriers, with some cells controlling viral replication after human ACE2 expression.

Identification of DAXX As A Restriction Factor Of SARS-CoV-2 Through A CRISPR/Cas9 Screen

The paper identifies DAXX as a restriction factor of SARS-CoV-2 through a CRISPR/Cas9 screen, showing it limits viral replication independently of SUMOylation.

The DEAD box RNA helicase DDX42 is an intrinsic inhibitor of positive-strand RNA viruses

This study identifies DDX42 as an intrinsic antiviral inhibitor that restricts HIV-1 and other positive-strand RNA viruses but not negative-strand RNA viruses.

The inflammasome components NLRP3 and ASC act in concert with IRGM to rearrange the Golgi during viral infections

The paper shows NLRP3 and ASC work with IRGM to rearrange the Golgi during viral infections like HCV and ZIKV.

RIG-I and PKR, but not stress granules, mediate the pro-inflammatory response to Yellow fever virus

This study identifies RIG-I and PKR as key mediators of the pro-inflammatory response to YFV in hepatocytes, showing that stress granules are not required for cytokine induction.

Y-RNAs Lead an Endogenous Program of RIG-I Agonism Mobilized upon RNA Virus Infection and Targeted by HIV

This study identifies Y-RNAs as endogenous RIG-I ligands that are targeted by HIV through DUSP11 downregulation, enhancing their immunogenicity and triggering antiviral responses.

Midgut barriers prevent the replication and dissemination of the yellow fever vaccine in Aedes aegypti

This study shows that YFV-17D replicates inefficiently in Aedes aegypti midgut and fails to disseminate, unlike a clinical isolate, due to midgut barriers.