M. Beretta

SARS-CoV-2 infection in domestic rats after transmission from their infected owner

This study shows SARS-CoV-2 Omicron can infect domestic rats, with one developing severe symptoms, suggesting rodents may contribute to viral spread and evolution.

Potent Human Broadly SARS-CoV-2 Neutralizing IgA and IgG Antibodies Effective Against Omicron BA.1 and BA.2

The paper identifies potent broadly neutralizing IgA and IgG antibodies against SARS-CoV-2 variants, including Omicron BA.1 and BA.2, from memory B cells in convalescents.

Variants with the N501Y mutation extend SARS-CoV-2 host range to mice, with contact transmission

The paper shows that SARS-CoV-2 variants with the N501Y mutation can infect and transmit to mice, suggesting potential for rodent reservoirs.

A monocyte/dendritic cell molecular signature of SARS-CoV2-related multisystem inflammatory syndrome in children (MIS-C) with severe myocarditis

The paper identifies a monocyte/dendritic cell gene signature in severe MIS-C with myocarditis, linked to NF-κB activity and cytokine signaling.

A roadmap for the characterization of energy metabolism in human cardiomyocytes derived from induced pluripotent stem cells

This study characterizes the metabolic profile of hiPSC-CM during maturation, showing increased oxidative capacity and altered substrate utilization over 12 weeks.

Ether lipid and sphingolipid expression patterns are G-protein coupled estrogen receptor 1-dependently altered in breast cancer cells

The paper identifies co-expression patterns of lipid classes in breast cancer cells, showing that ether lipids and sphingolipids are upregulated in G-protein coupled estrogen receptor 1-positive cells.

Heme induces innate immunity memory

This study shows heme induces trained immunity in human and murine cells, leading to long-term protection against bacterial sepsis through epigenetic and transcriptional changes.