Author

J. D. Schertzer

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Physiology· 5

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Approach:experimental assay· 5 Organism:mouse· 4 Research Focus:host-pathogen & immune response· 3 Research Focus:metabolism & bioenergetics· 3 Assay:proteomics· 3 Research Focus:cell signaling & trafficking· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

B. M. Duggan· 4 shared K. P. Foley· 3 shared N. G. Barra· 3 shared A. K. Tamrakar· 2 shared B. D. Henriksbo· 2 shared F. F. Anhe· 2 shared J. F. Cavallari· 2 shared A. C. Carpentier· 1 shared

Activity by Year

2020-2022 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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4 shared papersPhysiology

B. M. Duggan

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5 papers

Recent·Most cited

High-fructose feeding suppresses cold-stimulated brown adipose tissue glucose uptake in young men independently of changes in thermogenesis and the gut microbiome

G. Richard, D. P. Blondin, S. A. Syed, L. Rossi, M. E. Fontes, M. Fortin, S. Phoenix, F. Frisch, S. Dubreuil, B. Guérin, Éric E. Turcotte, M. Lepage, M. G. Surette, J. D. Schertzer, G. R. Steinberg, , A. C. Carpentier

This study shows high-fructose diets impair brown adipose tissue glucose uptake in young men without affecting thermogenesis, gut microbiome, or body mass.

bioRxiv · Jan 11, 2022Physiology

Gut microbiota-based vaccination engages innate immunity to improve blood glucose control in obese mice

B. M. Duggan, A. K. Tamrakar, N. G. Barra, F. F. Anhe, G. Paniccia, J. G. Wallace, H. D. Stacey, M. S. Miller, D. M. Sloboda, J. D. Schertzer

This study shows that gut microbiota-based vaccination improves blood glucose control in obese mice by engaging innate immunity, requiring bacterial components and specific immune proteins.

bioRxiv · Jul 15, 2021Physiology

Gut microbiota impairs insulin clearance during obesity

K. P. Foley, S. Zlitni, B. M. Duggan, N. Barra, F. F. Anhe, J. F. Cavallari, B. D. Henriksbo, C. Y. Chen, M. Huang, T. Lau, J. D. Schertzer

This study shows that gut microbiota impair insulin clearance during obesity, with specific bacterial taxa linked to this effect, suggesting potential therapeutic targets.

bioRxiv · May 8, 2020 · PreprintPhysiology

Inflammation promotes adipocyte lipolysis via IRE1 kinase

K. P. Foley, Y. Chen, N. G. Barra, M. Heal, K. Kwok, A. K. Tamrakar, W. Chi, B. M. Duggan, B. D. Henriksbo, Y. Liu, J. D. Schertzer

This study identifies IRE1 kinase as a mediator of inflammation-induced adipocyte lipolysis, distinct from adrenergic or hormonal regulation.

bioRxiv · Apr 7, 2020Physiology

RIPK2 dictates insulin responses to tyrosine kinase inhibitors in obese mice

B. M. Duggan, J. F. Cavallari, K. P. Foley, N. G. Barra, J. D. Schertzer

This study shows that RIPK2 limits the insulin sensitizing effect of gefitinib, while imatinib increases insulin secretion in obese mice, indicating TKI actions on RIPK2 dictate divergent insulin responses.

bioRxiv · Apr 3, 2020Physiology