B. M. Duggan

Nanoscaled discovery of a shunt rifamycin from Salinispora arenicola using a three-colour GFP-tagged Staphylococcus aureus macrophage infection assay.

The paper uses a GFP-tagged S. aureus macrophage infection assay to discover a novel rifamycin analogue with macrophage intracellular activity.

Gut microbiota-based vaccination engages innate immunity to improve blood glucose control in obese mice

This study shows that gut microbiota-based vaccination improves blood glucose control in obese mice by engaging innate immunity, requiring bacterial components and specific immune proteins.

Gut microbiota impairs insulin clearance during obesity

This study shows that gut microbiota impair insulin clearance during obesity, with specific bacterial taxa linked to this effect, suggesting potential therapeutic targets.

Commensal oral Rothia mucilaginosa produces enterobactin - a metal chelating siderophore

This study identifies Rothia mucilaginosa as a commensal oral bacterium producing enterobactin, a siderophore that affects the growth of pathogenic bacteria and may influence oral health.

Inflammation promotes adipocyte lipolysis via IRE1 kinase

This study identifies IRE1 kinase as a mediator of inflammation-induced adipocyte lipolysis, distinct from adrenergic or hormonal regulation.

RIPK2 dictates insulin responses to tyrosine kinase inhibitors in obese mice

This study shows that RIPK2 limits the insulin sensitizing effect of gefitinib, while imatinib increases insulin secretion in obese mice, indicating TKI actions on RIPK2 dictate divergent insulin responses.