J. Da Silva

Genomic surveillance of multidrug-resistant organisms based on long-read sequencing

This study demonstrates that long-read sequencing is as accurate and more cost-effective than short-read sequencing for molecular characterization of multidrug-resistant organisms.

Rab8, Rab11, and Rab35 coordinate lumen and cilia formation during Zebrafish Left-Right Organizer development

The paper shows Rab8, Rab11, and Rab35 coordinate membrane trafficking to synchronize cilia and lumen formation in zebrafish left-right organizer development.

Lipid Droplets Fuel Small Extracellular Vesicle Biogenesis

This study shows that lipid droplets are linked to small extracellular vesicle biogenesis and that manipulating lipid droplets can affect sEV secretion and cargo.

Neutralizing antibody-independent immunity to SARS-CoV-2 in hamsters and hACE-2 transgenic mice immunized with a RBD/Nucleocapsid fusion protein

This study shows that a RBD/Nucleocapsid fusion protein induces strong T cell responses and protects against SARS-CoV-2 without neutralizing antibodies in hamsters and hACE-2 mice.

High genetic barrier to escape from human polyclonal SARS-CoV-2 neutralizing antibodies

This study shows that multiple neutralizing epitopes in SARS-CoV-2 spike proteins are targeted by polyclonal antibodies, and 20 mutations can confer resistance, but vaccinated and infected individuals' plasma neutralizes these resistant variants and diverse sarbecoviruses.

Development of potency, breadth and resilience to viral escape mutations in SARS-CoV-2 neutralizing antibodies

This study examines how somatic mutations in SARS-CoV-2 antibodies affect their neutralization potency, breadth, and resistance to escape mutations across six antibody lineages.

An analysis of genetic diversity actions, indicators and targets in 114 National Reports to the Convention on Biological Diversity

This study quantitatively analyzes genetic diversity actions, indicators, and targets in 114 CBD National Reports, finding limited focus on wild species and inadequate monitoring indicators.