D. Poston

CD4-binding site immunogens elicit heterologous anti-HIV-1 neutralizing antibodies in transgenic and wildtype animals

This study shows that CD4bs immunogens can elicit potent, broad anti-HIV-1 neutralizing antibodies in transgenic and wildtype animals.

VPS29 exerts opposing effects on endocytic viral entry

The paper identifies VPS29 as a host factor that influences viral entry by modulating endosome properties, with opposing effects on coronavirus and influenza virus infections.

High genetic barrier to escape from human polyclonal SARS-CoV-2 neutralizing antibodies

This study shows that multiple neutralizing epitopes in SARS-CoV-2 spike proteins are targeted by polyclonal antibodies, and 20 mutations can confer resistance, but vaccinated and infected individuals' plasma neutralizes these resistant variants and diverse sarbecoviruses.

Mutational escape from the polyclonal antibody response to SARS-CoV-2 infection is largely shaped by a single class of antibodies

The paper maps mutations in SARS-CoV-2 spike RBD that escape binding by three antibody classes and finds that plasma escape maps closely resemble those of a single antibody class targeting site E484.

Development of potency, breadth and resilience to viral escape mutations in SARS-CoV-2 neutralizing antibodies

This study examines how somatic mutations in SARS-CoV-2 antibodies affect their neutralization potency, breadth, and resistance to escape mutations across six antibody lineages.

Derivation and Characterization of an inositol phosphate-independent HIV-1

This paper identifies an HIV-1 mutant that replicates without inositol hexaphosphate (IP6) and shows that the drug Bevirimat can functionally replace IP6 in certain conditions.

Escape from neutralizing antibodies by SARS-CoV-2 spike protein variants

The paper shows SARS-CoV-2 variants resistant to neutralizing antibodies can be selected and are present in circulating populations, suggesting the need for combination antibody therapies.