Author

M. K. Handzlik

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Biochemistry· 2 Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cell type annotation· 3 Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:metabolism & bioenergetics· 2 Assay:metabolomics· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1

Frequent Co-Authors

C. M. Metallo· 2 shared C. Metallo· 2 shared E. W. Lim· 2 shared M. S. Field· 2 shared A. B. Chan· 1 shared A. E. Thalacker-Mercer· 1 shared B. D. Cosgrove· 1 shared B. J. Gheller· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

2 shared papersBiochemistry

C. M. Metallo

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

BiochemistrybioRxivPreprintAug 29, 2022

Reduced methionine synthase (Mtr) expression creates a functional vitamin B12 deficiency that leads to uracil accumulation in mouse mitochondrial DNA

K. E. Heyden, J. L. Fiddler, Y. Xiu…·M. S. Field

This study shows that reduced Mtr expression causes B12 deficiency, leading to uracil accumulation in mtDNA and impaired mitochondrial function in mice.

DOI 10.1101/2022.08.29.505750

mouseDNA methylation

𝕏 PostBluesky

BiochemistrybioRxivApr 29, 2021

Metabolic adaptation to progressive mitochondrial dysfunction in aging POLGD257A mice

E. W. Lim, M. K. Handzlik, E. Trefts…·C. M. Metallo

This study examines metabolic changes in aging PolgD257A mice, revealing altered glycolysis, urea cycle dysfunction, and lipidome shifts linked to neuropathy.

DOI 10.1126/sciadv.abj4077

mousemetabolomics

𝕏 PostBluesky

PhysiologybioRxivOct 19, 2020

Daily running enhances molecular and physiological circadian rhythms in skeletal muscle

N. Casanova Vallve, D. Duglan, M. E. Vaughan…·K. A. Lamia

This study shows that daily running in mice changes their muscle circadian rhythms and improves exercise performance depending on the time of day.

DOI 10.1016/j.molmet.2022.101504

mousebulk RNA-seq

𝕏 PostBluesky

Cell BiologybioRxivPreprintNov 7, 2019

Serine and glycine are essential for human muscle progenitor cell population expansion

B. J. Gheller, J. E. Blum, E. L. Bender…·A. E. Thalacker-Mercer

This study identifies serine and glycine as essential for human muscle progenitor cell proliferation and shows their availability declines with age, impairing muscle regeneration.

DOI 10.1101/833798

humanproteomics

𝕏 PostBluesky