Author

J. E. Connolly

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Assay:flow cytometry· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:differential expression· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

A.-M. Fairhurst· 2 shared N. Kaliaperumal· 2 shared P. J. Ahl· 2 shared B. Au· 1 shared C. BONNARD· 1 shared C. K. LIM· 1 shared C. R. HARAPAS· 1 shared C.-I. Wang· 1 shared

Activity by Year

2020-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersImmunology

A.-M. Fairhurst

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Author profile →

3 papers

Recent·Most cited

Human NLRP1 is activated by ZAKa-driven ribotoxic stress response

K. S. ROBINSON, G. A. TOH, P. ROZARIO, S. BAYAT, Z. SUN, S. BAUERNFRIED, R. NADKARNI, C. R. HARAPAS, C. K. LIM, W. CHU, K. Y. TAN, C. BONNARD, R. SOBOTA, J. E. CONNOLLY, S. L. MASTERS, , F. L. Zhong

This paper identifies ZAKa-driven ribotoxic stress as a mechanism for activating human NLRP1, leading to pyroptosis in response to UVB and microbial ribotoxins.

bioRxiv · Jan 24, 2022 · PreprintImmunology

LAG3 is a Central Regulator of NK Cell Cytokine Production

S. Narayanan, P. J. Ahl, V. B. Au, N. Kaliaperumal, S. G. Lim, C.-I. Wang, A.-M. Fairhurst, J. E. Connolly

This study shows that LAG3 inhibits cytokine production in mature NK cells by enhancing glycolytic metabolism and is upregulated by IFN-.

bioRxiv · Jan 31, 2020 · PreprintImmunology

A novel strategy for single-cell metabolic analysis highlights dynamic changes in immune subpopulations

P. J. Ahl, R. A. Hopkins, W. W. Xiang, B. Au, N. Kaliaperumal, A.-M. Fairhurst, J. E. Connolly

The paper introduces Met-Flow, a flow cytometry-based method to analyze single-cell metabolism in immune cells, revealing that glucose restriction and metabolic remodeling drive the expansion of inflammatory central memory T cells.

bioRxiv · Jan 21, 2020Immunology